型号：GM-J#038495 -Available For Registering Interest

应用：Gli1-CreER knock-in/knock-out mice express a CreER fusion protein driven by the GLI-Kruppel family member GLI1 (Gli1) endogenous promoter, while abolishing endogenous Gli1 expression. When these mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in the Gli1-expressing cells of the offspring. These mice may be useful for studying axis patterning, proliferation, and cell fate specification of Hedgehog responding cells at different stages of embryogenesis.

型号：GM-J#038492 -Available

应用：Bmp10-CreERT2  are knock-in mice with an inducible icre/ERT2 fusion gene inserted into the bone morphogenetic protein 10 (Bmp10) gene. BMP10 is expressed in the hepatic stellate cells (HSCs) of the liver. These mice can be used as research tool to study liver fibrosis.

型号：GM-J#038448 -Available For Pre-Order

应用：These UFObow mice have a CAG promoter followed by three pairs of heterospecific lox sites (loxN, lox2272 and loxP) separating four fluorescent proteins. It functions as a Cre recombinase-inducible reporter of either a secreted luciferase (secNluc) or one of three blue-excitable fluorescent proteins.

型号：GM-J#038446 -Available For Pre-Order

应用：TetP-hA53T α-syn (line 4360) transgenic mice expresses the mutant human A53T alpha-synuclein under the control of the mouse prion protein (Prnp) gene promoter and the tetO, tetracycline-responsive regulatory element. When mated to a mutant strain expressing tTA, expression of SNCA*A53T protein may be regulated with the tetracycline analog doxycycline in the double mutant offspring. These mice may be useful in studying human neuronal alpha-synucleinopathies, such as familial Parkinson's Disease.

型号：GM-J#038436 -Available For Pre-Order

应用：Crybb1-iCre knock-in/knock-out mice have an iCre recombinase gene inserted into exon 1 of the crystallin, beta B1 (Crybb1) locus, abolishing endogenous Crybb1 expression. When these mice are bred with mice containing a loxP-flanked sequence of interest, Cre-mediated recombination will result in deletion of the floxed sequences in the Crybb1-expressing cells of the offspring. These mice may be useful for tracking microglia and border-associated macrophages (BAMS) during embryonic development.

型号：GM-J#038390 -Available For Registering Interest

应用：K14-Cre-ERT2 mice express a tamoxifen-inducible Cre recombinase/ERT2 fusion under the control of the human keratin K14 (KRT14) promoter/enhancer. Cre recombinase activity is observed in the basal layer of stratified squamous epithelia. This strain may be useful tool in studies of the epidermis.

型号：GM-J#038343 -Cryorecovery

应用：The CB2EGFP/f knock-in mice constitutively express an IRES-eGFP fusion sequence under the control of the endogenous cannabinoid receptor 2 (macrophage) gene promoter (Cnr2). These mice also possess loxP sites flanking exon 3 of the Cnr2 gene. These mice may be useful as a fluorescent reporter and in generating conditional mutations for studying neurodegenerative and neuroinflammatory diseases such as Alzheimer's disease (AD), multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS).

型号：GM-J#038342 -Cryorecovery

应用：Gas1-creER knock-in mice express an iCreER fusion protein driven by the growth arrest specific 1 (Gas1) endogenous promoter. When these mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in the Gas1-expressing cells of the offspring. These mice may be useful for studying cellular proliferation, apoptosis, embryonic development and tumor suppression in certain cancers.

型号：GM-J#038307 -Available

应用：ROSA26SAT translocation sensor mice conditionally express fluorescent ERK1/2 pathway, ATK pathway, and nuclear reporters from a single Gt(ROSA)26Sor transcript, enabling live-cell in vivo (whole embryo or animal) and ex vivo (cell line) studies of intracellular signaling in response to external stimuli.

型号：GM-J#038306 -Available

应用：ROSA26SAE translocation sensor mice conditionally express fluorescent ERK1/2 pathway and nuclear reporters from a single Gt(ROSA)26Sor transcript, enabling live-cell in vivo (whole embryo or animal) and ex vivo (cell line) studies of intracellular signaling in response to external stimuli.