型号：GM-J#038270 -Cryorecovery

应用：SynaCre CRISPR-derived knock-in mice are designed to have P2A-Cre sequence inserted immediately after the stop codon of the syncytin a gene. The endogenous Syna promoter directs expression of Cre recombinase to placental syncytiotrophoblasts (SCTB1). These mice are useful for studying gene functions in late gestation placentas, as well as for studying pregnancy complications and fetal abnormalities.

型号：GM-J#038257 -Cryorecovery

应用：KRT13-CreER knock-in mice express tamoxifen-inducible cre/ERT2 recombinase from the mouse keratin 13 (Krt13) promoter in hillock cells of the tracheal epithelium. This strain has been useful in hillock cell lineage tracing studies with implications for injury repair, squamous metaplasia, and lung cancer.

型号：GM-J#038210 -Available For Pre-Order

应用：Prkn-floxed mice possess loxP sites flanking exon 7 of the parkin RBR E3 ubiquitin protein ligase (Prkn) gene. These mice may be useful in generating conditional mutations to study the role of PRKN in multiple diseases caused by mitochondrial dysfunction, such early-onset Parkinson's disease.

型号：GM-J#038201 -Available For Pre-Order

应用：RARCre transgenic mice express Cre recombinase under the control of the murine retinoic acid receptor, beta (Rarb) promoter. They may be useful when studying cellular growth and differentiation.

型号：GM-J#038200 -Cryorecovery

应用：SynbCre CRISPR-derived knock-in mice are designed to have P2A-Cre sequence inserted immediately after the stop codon of the syncytin b gene. The endogenous Synb promoter directs expression of Cre recombinase to the placental syncytiotrophoblast 2 (SCTB2) layer of the placenta. These mice are useful for studying gene functions in late gestation placentas, as well as for studying pregnancy complications and fetal abnormalities.

型号：GM-J#038197 -Available

应用：Nmur1iCre-eGFP mice express iCre and eGFP driven by the neuromedin U receptor 1 (Nmur1) promoter. When these mice are bred with mice containing a loxP-flanked sequence of interest, Cre-mediated recombination will result in deletion of the floxed sequences in Nmur1-expressing cells of the offspring (Tsou et al., Nature 2022). These mice also express eGFP in Nmur1-expressing cells. These Nmur1iCre-eGFP mice may be useful for studying function and lineage mapping of Nmur1-positive cells.

型号：GM-J#038175 -Available For Registering Interest

应用：These hCD68-CreERT2 knock-in mice express an inducible cre/ERT2 fusion gene under the control of the human CD68 promoter. Following administration of tamoxifen, mice express Cre recombinase in CD11b+ F4/80+ macrophages, peritoneal, liver and spleen macrophages, and blood Ly6Clow monoctyes. These mice can be used to target tissue resident macrophages without targeting other myeloid cells.

型号：GM-J#038164 -Available For Pre-Order

应用：ROSA26-tdRFP knock-in mice allow cre-inducible expression of a robust tandem dimer RFP (tdRFP) fluorescent reporter from the ubiquitously expressed Gt(ROSA)26Sor locus. This strain may be useful as a tool that is compatible with GFP- or YFP-expressing mice for in vivo lineage tracing and fate-mapping studies.

型号：GM-J#038161 -Cryorecovery

应用：pTαiCre knock-in/knock-out mice carry a codon optimized Cre recombinase (icre) inserted into the Ptrca (pre T cell antigen receptor alpha) locus. Homozygous KO mice have decreased numbers of thymocytes. This strain may be useful for lineage tracing experiments in studies of T cell lymphopoiesis.

型号：GM-J#038152 -Available

应用：IgkTag (K-tag) knock-in mice have a loxP-flanked FLAG-tag, followed by stop codons and an SV40 polyadenylation sequence, and Strep-II tag inserted into the C-terminus of the immunoglobulin kappa chain complex (Igk) gene. Prior to Cre exposure, mice express FLAG-tagged B cell receptors. Upon Cre exposure, recombination of the loxP sites results in the removal of the FLAG-tag and expression of the Strep-II tag in Cre-expressing tissues. These mice allow for molecular fate-mapping of serum antibodies and can specifically be used to ascribe the cellular and temporal origin of serum antibodies to B cell reactions of interest.