型号：GM-J#038824 -Available For Pre-Order

应用：Myh11-CreERT2-P2A knock-in mice carry an inducible Cre recombinase-ERT2 fusion protein inserted into the Myh11 (myosin, heavy polypeptide 11, smooth muscle) locus. Mice have inducible cre expression in smooth muscle cells with minimal impact on endogenous Myh11 expression. This strain may be useful for research involving smooth muscle cells and smooth muscle cell-dependent cardiovascular diseases.

型号：GM-J#038823 -Available For Pre-Order

应用：Myh11-CreNLSP2A knock-in mice carry a codon optimized Cre recombinase (icre) fused to ERT2 inserted into the Myh11 (myosin, heavy polypeptide 11, smooth muscle) locus. Please note: tamoxifen administration does not further augment Cre activity, necessitating its use as a constitutive Cre model.  Mice have constitutive cre expression in smooth muscle cells without disrupting endogenous Myh11 expression. This strain may be useful for research involving smooth muscle cells and smooth muscle cell-dependent cardiovascular diseases.

型号：GM-J#038799 -Available For Pre-Order

应用：3RTau (Line 13) transgenic mice carry the mouse Thy1 promoter driving expression of human MAPT containing three ~32 amino acid repeats bearing the L266V and G272V mutations. These mice may be useful in studying neurodegenerative tauopathies, such as familial Pick's disease.

型号：GM-J#038796 -Available For Pre-Order

应用：Line 61 (mThy-1 hα-synuclein) transgenic mice express wildtype human α-synuclein cDNA driven by the mouse thymus cell antigen 1, theta (Thy1) promoter. These mice may be useful in studying human neuronal α-synucleinopathies, such as familial Parkinson's disease.

型号：GM-J#038775 -Available

应用：D Line (PDGFβ-hαsyn) transgenic mice express wildtype human α-synuclein cDNA driven by the platelet derived growth factor, B polypeptide (PDGFB) promoter. These mice may be useful in studying human neuronal α-synucleinopathies, such as familial Parkinson's disease.

型号：GM-J#038774 -Available For Pre-Order

应用：PDGFβ-hαsyn-eGFP transgenic mice have the human platelet-derived growth factor-β (PDGFB) promoter directing expression of the human α-synuclein (SNCA) gene fused to an enhanced green fluorescent protein (eGFP) in various neuronal cell types. These mice may be useful for visualizing the accumulation of α-synuclein in neuronal cell bodies in α-synucleinopathies, such as familial Parkinson's disease.

型号：GM-J#038773 -Available For Pre-Order

应用：SNCA*E57K(16) transgenic mice express human α-synuclein that contains an E57K amino acid substitution driven by the mouse thymus cell antigen 1, theta (Thy1) promoter. These mice may be useful in studying human neuronal α-synucleinopathies, such as familial Parkinson's disease.

型号：GM-J#038728 -Available For Pre-Order

应用：Ank2fl mice possess an frt-flanked cassette with an IRES-EGFP-polyA, a loxP site, and a neo cassette upstream of exon 4 of the Ankyrin 2, brain (Ank2) gene. Exon 4 is floxed, resulting in a total of 3 loxP sites. This strain may be useful for studying linker function between cytoskeleton and transmembrane protein in neurons associated with cardiac dysfunctions and the onset of Autism spectrum disorders (ASD) and seizures.

型号：GM-J#038709 -Available For Pre-Order

应用：B6.Spp1fl-EGFP-stop-tdTomato mutant mice possess loxP sites flanking sequence encoding exons 4-7 of the secreted phosphoprotein 1 gene and an EGFP sequence with a stop cassette. They also contain a tdTomato with a stop cassette downstream of the 3' loxP site. This strain may be useful for generating conditional mutants in applications related to bone growth/metabolism, cancer, and neurobiology.

型号：GM-J#038650 -Available For Pre-Order

应用：Crfr1-cre transgenic mice express icre and tdTomato under the control of the mouse Crhr1 promoter in neurons in the hypothalamic paraventricular nucleus (PVN). They may be useful for visualizing and studying growth and differentiation of CRFR1+ cells and neurons and their role of this microcircuit in regulating hypothalamic-pituitary-adrenal axis activity during stress responses.