型号：GM-J#038129 -Cryorecovery

应用：Ascl3P2A-GCE knock-in mice express an eGFP/iCreERT2 fusion protein in achaete-scute family bHLH transcription factor 3 (Ascl3)-expressing cells while retaining endogenous Ascl3 activity. When these mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre recombinase activity is detected in the Ascl3-expressing cells of the offspring. Of note, the donating investigator has indicated that eGFP expression is not detectable either by direct fluorescence or immunohistochemistry.

型号：GM-J#038113 -Cryorecovery

应用：Nps-2A-Cre CRISPR-derived knock-in mice are designed to have 2A-Cre sequence inserted downstream of the coding region of the neuropeptide S gene. The endogenous Nps promoter directs expression of Cre recombinase to neurons in the amygdala and in the brain stem near the parabrachial nucleus (PB) involved in wakefulness and anxiety-related behaviors. These mice are useful for studying the connectivity and function of NPS neurons.

型号：GM-J#038073 -Cryorecovery

应用：PSD95-lox-Stop-lox-TimeSTAMP2 mice have a loxP-flanked STOP codon and the TimeSTAMP cassette replacing the endogenous STOP codon of the Dlg4 gene. The TimeSTAMP (Time-Specific Tagging for the Age Measurement of Proteins) cassette contains N- and C-terminal Venus fragments separated by a cis-cleaving hepatitis C virus (HCV) NS3 protease, and a 2xHA-tag, expression of which is blocked by the presence of a loxP-flanked STOP cassette. After Cre induction, deletion of the STOP cassette allows the expression of PSD95-TimeSTAMP after administration of the NS3 inhibitor drug asunaprevir (ASV). This strain is useful for visualizing newly synthesized PSD95 where preservation of normal neuronal function is required.

型号：GM-J#038053 -Available

应用：Oprm1-cre knock-in mice express an eGFP/Cre fusion protein in opioid receptor, mu 1-expressing cells while retaining endogenous Oprm1 activity. These mice may be used for studying the expression and activity pattern of Oprm1-expressing cells.

型号：GM-J#038021 -Available For Pre-Order

应用：MI2 mice harbor an α-Syn null allele and a truncated (1-120) human α-synuclein transgene driven by the rat Th promoter. These mice may be useful for studying the pathogenic role of α-synuclein in synucleinopathies, such as Parkinson's Disease.

型号：GM-J#037964 -Cryorecovery

应用：Vip-IRES-Cre mice have Cre recombinase expression directed to Vip-expressing cells by the endogenous promoter/enhancer elements of the vasoactive intestinal polypeptide locus. Cre activity is detected in the neocortex, hippocampus, olfactory bulb, suprachiasmatic nuclei, and other discrete midbrain and brainstem regions. These mice may be useful to study neural GABAergic circuits throughout the mammalian brain.

型号：GM-J#037963 -Cryorecovery

应用：Sst-IRES-Cre knock-in mice express Cre recombinase in somatostatin-expressing neurons. These mice may be useful in studying dendritic inhibitory interneurons such as Martinotti cells and Oriens-Lacunosum-Moleculare cells.

型号：GM-J#037946 -Available For Registering Interest

应用：RCL-dCreV mice have a loxP-flanked STOP cassette preventing expression of a split, destabilized, light-inducible Cre recombinase. Following exposure to another Cre recombinase source and then subsequent illumination of the appropriate wavelength (~920nm) in the presence of the stabilizing antibiotic trimethoprim (TMP), expression of a functional Cre recombinase enzyme complex is expected. These mice are useful for in vivo targeted optogenomic modifications of single cells or cell populations.

型号：GM-J#037939 -Available For Pre-Order

应用：Ai203 (also called Ai203(TITL-sChroME-Kv2.1-GC7s-WPRE-ICL-nls-mRuby3-IRES2-tTA2-WPRE)) is a Cre recombinase-dependent, Tet-controllable, optogenetic, calcium sensor and fluorescent tool allele created by targeted insertion at the Igs7 locus (TIGRE). Exposure to Cre recombinase results in expression of sChroME*/GCaMP7s, mRuby3, and tTA2 in those cells where cre is expressed.

型号：GM-J#037890 -Available

应用：Rosa26TurboID knock-in mice have the widely-expressed CAG promoter controlling the cre-inducible expression of a V5-tagged biotin ligase sequence, TurboID, with a nuclear export signal. Cre-mediated recombination results in the excision of a STOP sequence, enabling cell-type specific expression of TurboID. These mice provide a tool for in vivo biotinylation of proteins allowing characterization of specific proteomes in multiple tissues.