型号：GM-J#008464 -Cryorecovery

应用：These knock-in mice express a tamoxifen-inducible cre recombinase from the endogenous promoter/enhancer elements of the forkhead box A2 (Foxa2) locus. When induced, cre activity is observed in the developing endoderm, notochord, and floorplate.

型号：GM-J#008463 -Available Now

应用：This strain enables temporal control of floxed gene expression by tamoxifen induction in vivo.

型号：GM-J#008454 -Available

应用：These Sox2Cre transgenic mice express Cre recombinase under the control of the mouse Sox2 (SRY-box containing gene 2) promoter, and may be useful for generating epiblast-derived specific conditional mutations.

型号：GM-J#008389 -Cryorecovery

应用：This transgenic strain carries a human THY1 promoter driving expression of the human synuclein, alpha (SNCA) gene. Levels of expression show a 5-fold increase in the brain and a 10-fold increase in the spinal cord. Hemizygotes are viable and fertile and unlike some similar mutant transgenic lines, do not display any Parkinson-like phenotype upon aging.

型号：GM-J#008364 -Cryorecovery

应用：These targeted mutation mice carry a tamoxifen-inducible Cre cassette knocked into the 3' UTR of the Chat, choline acetyltransferase gene. When crossed with a strain containing a loxP site flanked sequence of interest, the offspring are useful for generating 4-hydroxytamoxifen-induced, Cre-mediated targeted deletions specifically in cholinergic neurons.

型号：GM-J#008363 -Cryorecovery

应用：These targeted mutation mice carry a tamoxifen-inducible Cre cassette knocked into the 3' UTR of the Nefl, neurofilament, light polypeptide gene. When crossed with a strain containing a loxP site flanked sequence of interest, the offspring are useful for generating 4-hydroxytamoxifen-induced, Cre-mediated targeted deletions specifically in large neurons.

型号：GM-J#008333 -Cryorecovery

应用：These Dld (dihydrolipoamide dehydrogenase or E3 component) mutant mice may be useful to study early murine embryonic metabolism, including glucose and mitochondrial metabolism during the early postimplantation period. As altered energy metabolism and reductions in alpha-ketoacid dehydrogenase complexes have also been associated with many neurodegenerative disorders, these mice may also be useful in studies related to Parkinson's disease, Huntington's disease, and/or Alzheimer's disease. Because the metabolic disturbances associated with E3 deficiency (Dld deficiency) cause a variant of Maple Syrup Urine Disease (MSUD) in which there is an accompanying lactic acidosis due to concomitant deficiency of pyruvate dehydrogenase complex, these mice may be useful in such studies or in conjunction with iMSUD mice (Stock No. 006999).

型号：GM-J#008330 -Cryorecovery

应用：A melanocortin 4 receptor (Mc4r) promoter drives expression of Cre in this transgenic line. When crossed with a strain containing loxP site flanked sequence of interest, Cre-mediated recombination occurs in all cells normally expressing MC4R.

型号：GM-J#008320 -Available

应用：Cre activity is demonstrable in the hypothalamus, limbic and cortical brain regions, and retrosplenial cortex of these knock-in Lepr mice. When bred with a mouse containing a loxP site-flanked sequence of interest, Cre-mediated recombination results in deletion of the flanked genome in tissues that normally express the targeted gene. This strain has been used in virus-assisted mapping of neural inputs and may be useful in studies of neural features of feeding behaviors.

型号：GM-J#008314 -Cryorecovery

应用：These transgenic mice express Cre recombinase under the control of the human beta hemoglobin (HBB) promoter and intron 2-enhancer fragment, and the human beta hemoglobin locus control region (LCR). When crossed with a strain containing a loxP site-flanked sequence, Cre-mediated recombination results in deletion of the targeted sequence in erythroid tissues. These Cre recombinase expressing mutant mice may be useful in generating tissue specific-targeted mutants useful in studies of erythropoiesis and hematopoiesis.