型号：GM-J#008134 -Cryorecovery

应用：The A30P mutation in this transgenic strain is associated with the development of familial Parkinson's disease. The onset of hind limb mobility problems occurs around 12 months of age (sometimes earlier), induced by a loss of motor neurons and associated with the formation of insoluble alpha synuclein aggregates. This strain may be useful in studies of Parkinson's disease.

型号：GM-J#008133 -Cryorecovery

应用：These mice possess loxP sites on either side of exon 2 of the targeted gene. Mice that are homozygous for this allele are viable, normal in size and do not display any gross physical or behavioral abnormalities, but breed very poorly. Protein levels are normal. When bred to a strain expressing Cre recombinase, this mutant mouse strain may be useful in studies of presynaptic proteins and synaptic vesicles.

型号：GM-J#008132 -Cryorecovery

应用：M1m transgenic mice overexpress wildtype mouse Snca (synuclein, alpha) cDNA under the control of a mouse Thy1 (thymus cell antigen 1, theta) promoter. Mice hemizygous for this transgene are viable and fertile and do not display any gross physical or behavioral abnormalities, even upon aging.

型号：GM-J#008122 -Cryorecovery

应用：When these RIP-CreER mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in pancreatic beta cells. This mutant mouse strain may be useful in studying pancreatic development, diabetes and obesity.

型号：GM-J#008119 -Cryorecovery

应用：When these Ngn3/CreERTM mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Neurog3 expressing cells such as pancreatic islet cells and undifferentiated spermatogonia. This mutant mouse strain may be useful for studying pancreatic development and lineage mapping of Neurog3 expressing cells.

型号：GM-J#008085 -Cryorecovery

应用：The UBC-Cre-ERT2 transgenic strain backcrossed 11 or more generations to C57BL/6 is available as Stock No. 007001. The UBC-Cre-ERT2 transgenic strain backcrossed ~6 or more generations to C57BL/6 (Stock No. 008085) is available via cryo recovery.

型号：GM-J#008084 -Cryorecovery

应用：These D4R-mutant mice harbor a dopamine receptor 4 (Drd4; also called dopamine D4 receptor (D4R)) targeted mutation where exon 2 is replaced with a neomycin resistance cassette, and may be useful in studying dopamine/neurotransmitter function, drug addiction, Parkinson's disease, and schizophrenia or other psychoses.

型号：GM-J#008069 -Cryorecovery

应用：A C57BL/6J congenic version of this strain is available as Stock No. 017320.

型号：GM-J#008068 -Available

应用：Mice harboring the Itgax-cre (Cd11c-Cre) BAC transgene express Cre recombinase under control of the integrin alpha X gene (Itgax or Cd11c) promoter/enhancer regions within the BAC transgene. These Cd11c-Cre transgenic mice are a Cre-lox tool for deletion of floxed sequences in CD8-, CD8+ dendritic cells, tissue-derived dendritic cells from lymph nodes, lung and epidermis, as well as plasmacytoid dendritic cells. This strain may be useful for studying dendritic cell homeostasis and function.

型号：GM-J#007924 -Cryorecovery

应用：En2-CreERT2 mutant mice harbor the Cre-ERT2 fusion gene under control of the endogenous engrailed 2 locus. When En2-CreERT2 mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in En2-expressing tissues (including the developing mesencephalon, rhombomere 1, and jaw muscles, as well as the embryonic and adult cerebellum).