型号：GM-J#008533 -Cryorecovery

应用：These transgenic mice express the Cre recombinase under the control of the mouse chondroitin sulfate proteoglycan 4 (Cspg4) promoter/enhancer. Cre recombinase expression is detected in Cspg4 expressing glial cells and vasculature throughout the brain as well as in Cspg4-expressing cells in other tissues from late embryonic stages (~embryonic day 14) throughout adulthood. These transgenic mice may be may be crossed to various floxed mutants to delete floxed sequences specifically in Cspg4-expressing cells.

型号：GM-J#008532 -Cryorecovery

应用：These knock-in mice express a tamoxifen-inducible cre recombinase. When induced, cre activity is observed in dopaminergic neurons in the brain.

型号：GM-J#008531 -Cryorecovery

应用：This creER knock-in line can be used to produce Vamp2 (vesicle-associated membrane protein 2) gene recombination in many diverse types of neurons following 4-hydroxytamoxifen treatment. Heterozygotes are normal in size and viability. Homozygotes of both genders have reduced viability.

型号：GM-J#008529 -Cryorecovery

应用：When these Ngn1-CreERT2 transgenic mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Neurog1 expressing cells such as neurons in the cortex, hippocampus, thalamus, hypothalamus and the cochlear-vestibular ganglion. This mutant mouse strain may be useful for studying neuron development and lineage mapping of Neurog1 expressing cells.

型号：GM-J#008523 -Cryorecovery

应用：These 129S6 Podocin-Cre mice (harboring the p2.5P-Cre transgene) have expression of Cre recombinase directed to podocytes within kidney glomeruli by the human podocin (NPHS2) promoter/enhancer region and may be useful in generating Cre-lox conditional knockouts for studying the role of podocyte nephrobiology in renal disorders.

型号：GM-J#008520 -Cryorecovery

应用：Mice harboring the hCD2-iCre transgene have the human CD2 promoter and locus control region (LCR) directing expression of an optimized variant of Cre recombinase (iCre) to T cells and B cells (all B cell and T cell progenitors) and mice may be useful for generating conditional mutations in T cells and B cells. Because of the integration site of the transgene, the hCD2-iCre transgene is linked to the agouti coat color genes.

型号：GM-J#008516 -Cryorecovery

应用：Homozygous ROSA26 GNZ knock-in mice have widespread expression of a nuclear-localized green fluorescent protein/beta-galactosidase fusion protein (GFP-NLS-lacZ or GNZ) once an upstream loxP-flanked STOP sequence is removed. When bred to cre expressing mice, the resulting GNZ fusion protein expression in the offspring allows for enhanced (single cell level) visualization.

型号：GM-J#008513 -Cryorecovery

应用：A loxP-flanked neomycin cassette blocks expression of the rat Trpv1 (transient receptor potential cation channel, subfamily V, member 1) gene driven by the Gt(ROSA)26Sor gene in this targeted mutation/knock-in strain. Upon crossing to a tissue-specific Cre-expressing strain, TRPV1 and enhanced cyan fluorescent protein (ECFP) is expressed from the ROSA locus. Cells expressing TRPV1 are sensitive to capsaicin and similar chemical agonists. Treatment of mice or cells that have undergone Cre excision to remove the neomycin cassette can induce strong inward currents, trigger action potentials and activate stereotyped behaviors, allowing cell-type specific chemical genetic control of neuronal activity in vitro and in vivo. These mice may also be useful in studies of TCR signalling in T cells.

型号：GM-J#008474 -Cryorecovery

应用：These mice are transgenic for the A53T mutation of the human SNCA (synuclein, alpha) gene under the control of a human THY1 (thymus cell antigen 1, theta) promoter. Hemizygotes are viable and fertile and develop a Parkinson-like phenotype upon aging. Hind limb paralysis due to loss of motor neurons and a resting tremor are initially seen at about eight months of age. No Lewy body-like pathology is noted. Cell death in the spinal cord (extensive) and brain are observed.

型号：GM-J#008473 -Cryorecovery

应用：This strain carries an A30P mutant form of the human SNCA (synuclein, alpha) gene associated with the development of familial Parkinson's disease. The onset of hind limb mobility problems and a resting tremor phenotype occur around 10 months of age due to a loss of motor neurons. No Lewy body-like pathology has been observed. Extensive cell death in the spinal cord and brain are seen. This strain may be useful in studies of Parkinson's disease. Hemizygous mice are viable and fertile, and survive to approximately 14 months of age.