型号：GM-J#008678 -Cryorecovery

应用：These mice have a GFP-puror fusion protein "knock-in" mutation of the Ubb (ubiquitin B) gene that also abolishes endogenous gene function and may be useful for fluorescent labeling and/or Ubb-deficiency in studying gametogenesis, meiosis, neuron development and survival, neuropathogenic disease, and adult-onset obesity linked to selective hypothalamic neurodegeneration.

型号：GM-J#008661 -Available

应用：These Nkx2.1Cre (or BAC-Nkx2.1-Cre) transgenic mice express cre under the control of the Nkx2.1 promoter/enhancer regions and may be useful for generating conditional mutations for studying gain/loss of function or fate mapping in subgroups of brain progenitor cells (interneurons in telencephalon and hypothalamus cells), as well as developing lung, thyroid, and pituitary tissues.

型号：GM-J#008610 -Available

应用：Vav-iCre transgenic mice have the mouse HS21/45 control regions directing expression of an optimized variant of Cre recombinase (iCre) to hematopoietic cells (and their progenitors), and may be useful for generating conditional mutations in hematopoietic cells.

型号：GM-J#008606 -Cryorecovery

应用：Homozygous ROSA26 GNZ knock-in mice have widespread expression of a nuclear-localized green fluorescent protein/beta-galactosidase fusion protein (GFP-NLS-lacZ or GNZ) once an upstream loxP-flanked STOP sequence is removed. When bred to cre expressing mice, the resulting GNZ fusion protein expression in the offspring allows for enhanced (single cell level) visualization.

型号：GM-J#008605 -Cryorecovery

应用：These IRG transgenic mice are a double-fluorescent, Cre-reporter strain; with widespread expression of red fluorescence prior to Cre recombinase exposure, and green fluorescence following cre-mediated recombination in a pattern determined by cre expression, and should provide a versatile tool for analyzing complex cellular relationships in a wide variety of tissues.

型号：GM-J#008601 -Available

应用：TH-Cre transgenic mice have the rat tyrosine hydroxylase (TH) promoter directing expression of Cre recombinase to catecholaminergic cells, and may be useful for generating conditional mutations in these cells for studying dopaminergic cell function, Parkinson's disease, and other neurodegenerative disorders.

型号：GM-J#008569 -Cryorecovery

应用：This strain expresses Cre recombinase from the targeted Alpl (alkaline phosphatase, liver/bone/kidney) locus. These mice may be useful for generating tissue-specific deletions, primarily in embryonic primordial germ cells, for applications related to reproductive and endocrine systems development.

型号：GM-J#008538 -Available

应用：These NG2CreERTM BAC transgenic mice express a tamoxifen-inducible Cre recombinase (CreERTM) under the control of the mouse NG2 (Cspg4) promoter/enhancer. When bred with mice containing loxP-flanked sequences, tamoxifen-inducible Cre-mediated recombination is expected to result in deletion of the floxed sequences in the Cre recombinase-expressing tissues of the offspring. These NG2CreERTM BAC transgenic mice may be useful for inducible Cre recombinase expression in NG2-expressing glia (polydendrocytes, oligodendrocyte progenitor cells) in the central nervous system and NG2-expressing cells in other organs.

型号：GM-J#008537 -Cryorecovery

应用：Mice harboring the Tg(Tek-cre)2352Rwng (Tie2Cre) transgene express the Cre recombinase under the control of the mouse Tek, endothelial-specific receptor tyrosine kinase (also known as Tie2), promoter and may be useful for generating endothelial cell specific-targeted conditional mutations.

型号：GM-J#008535 -Available

应用：These transgenic mice express a codon-improved Cre recombinase (iCre) under the control of the mouse Pf4 (platelet factor 4), or Cxcl4, promoter. Cre recombinase expression is detected in the majority of megakaryocytes, as well as in borderzone macrophages in the CNS. This strain represents an effective tool for generating megakaryocyte lineage-restricted specific-targeted mutants.