型号：GM-J#008827 -Cryorecovery

应用：Prdm1-Cre (Blimp1-Cre) transgenic mice express Cre recombinase under the control of the mouse Prdm1 promoter. These mice may be useful for generating tissue-specific targeted mutants for studies of development and germ cell fate.

型号：GM-J#008820 -Cryorecovery

应用：This Wlds spontaneous mutant mouse strain may be useful in studies of peripheral nerve regeneration and neurodegenerative disorders.

型号：GM-J#008813 -Cryorecovery

应用：This Trpa1CKO;pCAGGCre-ERTM compound mutant has a floxed allele of the Trpa1 (transient receptor potential cation channel, subfamily A, member 1) gene in addition to a tamoxifen inducible cre transgene driven by the chicken beta actin promoter/enhancer coupled with the cytomegalovirus (CMV) immediate-early enhancer (see Stock No. 004682). Restricted to the cytoplasm, the cre/Esr1 protein can only gain access to the nuclear compartment after exposure to tamoxifen. Tamoxifen administration induces cre recombination within the Trpa1 allele, excising the S5/S6 transmembrane domains. Animals not treated with tamoxifen display no observable phenotype.

型号：GM-J#008783 -Cryorecovery

应用：The severely affected "rescuable" SMA model mice, SMN2;Δ7;Cre-ER;SmnRes/Res, allow tamoxifen-inducible rescue of Type II (moderate) proximal spinal muscular atrophy.

型号：GM-J#008781 -Cryorecovery

应用：These transgenic mice express improved Cre recombinase (iCre) under the control of the mouse kidney androgen regulated protein (Kap). Transgene induction occurs with endogenous androgen (testosterone) treatment. Cre recombinase expression is detected in the proximal tubule cells of the renal cortex in male mice. When crossed with a strain containing loxP site flanked sequence of interest, Cre-mediated recombination results in deletion of the targeted gene in the proximal tubule cells of the kidney.

型号：GM-J#008766 -Available

应用：These Cd8a-Cre transgenic mice (Stock No. 008766) have Cre recombinase activity observed in peripheral CD8+ T cells (CD8α+CD8β+ αβT cells and CD8α+CD8β- αβT cells, but not in CD4+CD8α-CD8β- αβT cells). The transgenic construct also contains GFP, which co-expresses with Cre, but the GFP expression is very low via flow cytometry. These mice may be useful for deletion of loxP-flanked sequences in CD8a-expressing cells.

型号：GM-J#008735 -Cryorecovery

应用：WAP-Cre transgenic mice have expression of Cre recombinase directed to mammary gland secretory epithelial cells by the mouse Wap (whey acidic protein) promoter, and may be used to generate conditional knockouts for studying breast cancer and lactation (for example).

型号：GM-J#008712 -Cryorecovery

应用：These Twist2-cre (or, Dermo1-cre) mutant mice harbor a Cre recombinase knock-in allele that also abolishes endogenous twist homolog 2 (Drosophila) (Twist2) gene function. They may be useful for Cre-lox applications/Twist2-deficiency research in embryogenesis of mesoderm-derived tissues (including chondrocytes and osteoblasts), as well as NF-kappaB transcription factor/cytokine signaling pathways.

型号：GM-J#008705 -Cryorecovery

应用：These IRG transgenic mice are a double-fluorescent, Cre-reporter strain; with widespread expression of red fluorescence prior to Cre recombinase exposure, and green fluorescence following cre-mediated recombination in a pattern determined by cre expression, and should provide a versatile tool for analyzing complex cellular relationships in a wide variety of tissues.

型号：GM-J#008694 -Cryorecovery

应用：Enhanced green fluorescent protein is expressed in FoxP3+ T cells. These Foxp3-GFP/cre mice may be useful in studies of regulatory T cell function in autoimmunity.