型号：GM-J#008303 -Cryorecovery

应用：This Tcfe2a, transcription factor E2a, targeted mutation strain may be useful in generating conditional mutations for studying B and T cell development and for other immunological applications.

型号：GM-J#008245 -Cryorecovery

应用：These hwα-SYN-5 transgenic mice may be useful for studying Parkinson's disease, Lewy bodies, neurodegeneration, and synaptic plasticity in conjunction with Stock No. 008239.

型号：GM-J#008244 -Cryorecovery

应用：This strain represents an effective tool for generating inducible, tissue-specific-targeted mutants to study cell lineage during development.

型号：GM-J#008239 -Cryorecovery

应用：These transgenic mice, sometimes referred to as hm2α-SYN-39, contain a mutated human alpha synuclein protein found in human Parkinson Disease patients and under the control of the rat tyrosine hydroxylase promoter. Expression is detected in cell bodies, axons, and terminals of the nigrostriatal system.

型号：GM-J#008226 -Cryorecovery

应用：These piGAP transgenic reporter mice have expression of the eGFP-F-IRES-hPLAP dicistronic gene blocked by an unpstream loxP-flanked STOP-polyA sequence. When bred to mice that express Cre recombinase, the resulting offspring will have the STOP-polyA sequence deleted in the cre-expressing tissue(s),

型号：GM-J#008208 -Cryorecovery

应用：These Stra8-cre transgenic mice have expression of Cre recombinase (iCre) directed by the Stra8 genomic promoter fragment, and may be useful in generating conditional knockouts in postnatal, premeiotic, male germ cells for studying spermatogenesis.

型号：GM-J#008205 -Available

应用：These transgenic mice (commonly referred to as podocin-Cre mice) have expression of Cre recombinase directed to podocytes within kidney glomeruli by the human podocin (NPHS2) promoter/enhancer region and may be useful in generating Cre-lox conditional knockouts for studying the role of podocyte nephrobiology in renal disorders.

型号：GM-J#008200 -Cryorecovery

应用：These piGAP transgenic reporter mice have expression of the eGFP-F-IRES-hPLAP dicistronic gene blocked by an upstream loxP-flanked STOP-polyA sequence. When bred to mice that express Cre recombinase, the resulting offspring will have the STOP-polyA sequence deleted in the cre-expressing tissue(s), permitting dicistronic expression of human Placental Alkaline Phosphatase (PLAP or ALPP) and farnesylated Enhanced Green Fluorescent Protein (eGFP-F; optimized to target expression to the cytoplasmic side of the plasma membrane). These piGAP transgenic reporter mice allow Cre-inducible, eGFP-F and hPLAP expression in multiple cell and tissue types.

型号：GM-J#008199 -Cryorecovery

应用：These Dlx5/6-Cre transgenic mice have Cre recombinase expression directed by the regulatory sequences of the zebrafish dlx5a/dlx6a genes and may be useful in generating specific deletions of floxed alleles in GABAergic in forebrain and other brain regions.

型号：GM-J#008135 -Cryorecovery

应用：Hemizygous transgenic mice are viable and fertile and develop a Parkinson-like phenotype upon aging. Hind limb paralysis due to loss of motor neurons and a resting tremor are initially seen at about six months of age. No Lewy body-like pathology is noted. Cell death in the spinal cord (extensive) and brain are observed.