型号：GM-J#009347 -Cryorecovery

应用：Mice homozygous for the LRRK2 R1441C knockin (R1441C KI) express the R1441C mutant form of leucine-rich repeat kinase 2 (Lrrk2) associated with Parkinson's disease. These LRRK2 R1441C KI mice may be useful in studying abnormal regulation of activity-dependent dopamine neurotransmission and D2 receptor-mediated function, which may represent pathogenic precursors preceding dopaminergic degeneration in Parkinson's disease.

型号：GM-J#009346 -Cryorecovery

应用：Mice homozygous for the LRRK2 R1441C knockin allele express the R1441C mutant form of leucine-rich repeat kinase 2 (Lrrk2) associated with Parkinson's disease. These LRRK2 R1441C KI mice may be useful in studying abnormal regulation of activity-dependent dopamine neurotransmission and D2 receptor-mediated function, which may represent pathogenic precursors preceding dopaminergic degeneration in Parkinson's disease.

型号：GM-J#009253 -Cryorecovery

应用：This strain carries an inverted human placental alkaline phosphatase (ALPP; PLAP) coding segment flanked by oppositely-oriented loxP sites integrated in the Gt(ROSA)26Sor gene. Cre excision of the floxed segment flips rather than excises the ALPP inversion and reinstates a transcriptionally active form of the gene. This reporter can be activated by tissue-specific cre recombinase in any cell in the body at any time in development. The result is very clear ALPP enzyme activity that can be detected histochemically.

型号：GM-J#009155 -Cryorecovery

应用：This targeted strain expresses Cre under the control of the claudin 6 promoter. When bred to a floxed reporter strain, broad expression throughout the epiblast is seen at E6.5. By E9.5, expression is restricted to the endoderm-derived structures such as the oral cavity, digestive tract, and lung. In addition, it is expressed in mesonephros and otic vesicle.

型号：GM-J#009117 -Cryorecovery

应用：These Cyp39a1-Tg7-Cre mice express Cre recombinase under the control of the Cyp39a1 (cytochrome P450, family 39, subfamily a, polypeptide 1) promoter/enhancer regions, and may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping in subgroups of brain tissues (including cortex, hippocampus and cerebellum).

型号：GM-J#009112 -Cryorecovery

应用：These Scnn1a-Tg2-Cre mice express Cre recombinase under the control of the Scnn1a (sodium channel, nonvoltage-gated 1 alpha) promoter/enhancer regions, and may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping in subgroups of brain tissues (including cortex, thalamus, midbrain and cerebellum).

型号：GM-J#009111 -Cryorecovery

应用：These Scnn1a-Tg1-Cre mice express Cre recombinase under the control of the Scnn1a (sodium channel, nonvoltage-gated 1 alpha) promoter/enhancer regions, and may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping in subgroups of brain tissues (including cortex, striatum, hippocampus and cerebellum).

型号：GM-J#009107 -Cryorecovery

应用：Wnt-1/GAL4/cre-11 transgenic mice were created by co-injection of both the pWEXP2-GAL4 transgene (Wnt1-GAL4) and the pWEXP3C-cre transgene (Wnt1-Cre). Transgenic mice have the wingless-related MMTV integration site 1 (Wnt1) promoter/regulatory sequences directing expression of both Cre recombinase and the GAL4 transcriptional activator to midbrain and developing neural tube.

型号：GM-J#009103 -Cryorecovery

应用：These Wfs1-Tg3-CreERT2 mice express a tamoxifen-inducible Cre recombinase under the control of the mouse Wfs1 (Wolfram syndrome 1 homolog (human)) promoter/enhancer regions, and may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping in subgroups of brain tissues (including cortex, hippocampus, striatum, thalamus and cerebellum).

型号：GM-J#009102 -Cryorecovery

应用：Mice harboring this mNF-H-cre transgene have nuclear localized-Cre recombinase expression directed primarily to cortex and hippocampus neurons coinciding the late stages of brain development by the mouse neurofilament-H gene promoter. These mice may be useful in generating conditional knockouts for neurobiological, neurodevelopmental, neuromuscular, amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease), or aging studies involving the neurons of the brain and spinal cord.