型号：GM-J#009090 -Cryorecovery

应用：This transgenic strain carries a modified Slc6a3-parkin-Q311X (a FLAG-tagged mutant human parkin gene) BAC. These mice are useful for studying Parkinson's disease pathogenesis and neurodegeneration.

型号：GM-J#009074 -Cryorecovery

应用：These transgenic mice express nuclear-localizing Cre recombinase under the control of the mouse Myh6 (myosin, heavy polypeptide 6, cardiac muscle, alpha; alpha-MHC) promoter. Cre recombinase expression is detected in a majority of cardiac myocytes.

型号：GM-J#009061 -Cryorecovery

应用：These mice harbor a Osr1eGFPCreERt2 (Osr1GCE) "knock-in" allele that both abolishes Osr1 (odd-skipped related 1 (Drosophila)) gene function and expresses EGFP and creERT2 from the Osr1 promoter/enhancer elements. While EGFP expression is observed in intermediate mesoderm and dorsal lateral plate mesoderm of developing embryos (~E8.5), Cre-ERT2 fusion gene activity is inducible; observed in the same cells only following tamoxifen administration. These Osr1GCE mice may be useful for lineage-tracing/marking Osr1-expressing cells for studying metanephric kidney development, as well as vascular, heart, and urogenital development.

型号：GM-J#009044 -Cryorecovery

应用：A loxP-flanked puromycin resistance/STOP cassette followed by a fusion of firefly luciferase and synthetic antigen peptide SIYRYYGL were introduced to the Gt(ROSA)26Sor (gene trap ROSA 26, Philippe Soriano) locus. After Cre activity, the recombined locus has high expression of Luciferase-SIY fusion protein. This mutant mouse strain may be useful in studies of immune response to a self-antigen or over-expressed tumor-associated antigen when used in combination with tumor-prone models.

型号：GM-J#009043 -Cryorecovery

应用：A loxP-flanked puromycin resistance/STOP cassette followed by a fusion of firefly luciferase and synthetic antigen peptide SIYRYYGL were introduced to the Gt(ROSA)26Sor (gene trap ROSA 26, Philippe Soriano) locus. After Cre activity, the recombined locus has high expression of Luciferase-SIY fusion protein. This mutant mouse strain may be useful in studies of immune response to a self-antigen or over-expressed tumor-associated antigen when used in combination with tumor-prone models.

型号：GM-J#008889 -Cryorecovery

应用：These ROSA26-Syn119 mice allow cre-inducible expression of the Syn119 C-terminally truncated mutation of human alpha-synuclein (human α-Syn119 or SynCT119; associated with familial Parkinson's disease), and may be useful for studying the progressive dopaminergic neurodegeneration of Parkinson's disease and other synucleinopathies, Lewy bodies, and synaptic plasticity.

型号：GM-J#008886 -Cryorecovery

应用：These ROSA26-Syn-E46K mice allow cre-inducible expression of the E46K missense mutant form of human alpha-synuclein (human E46K α-Syn or SYNE46K) associated with familial Parkinson's disease, dementia, and visual hallucinations, and may be useful for studying the progressive dopaminergic neurodegeneration of Parkinson's disease and other synucleinopathies, Lewy bodies, and synaptic plasticity.

型号：GM-J#008883 -Cryorecovery

应用：These ROSA26-Syn-A53T mice allow cre-inducible expression of the familial Parkinson's disease-associated A53T missense mutant form of human alpha-synuclein (human A53T α-Syn or SYNA53T), and may be useful for studying the progressive dopaminergic neurodegeneration of Parkinson's disease and other synucleinopathies, Lewy bodies, and synaptic plasticity.

型号：GM-J#008875 -Available

应用：Heterozygous mice harbor an Lgr5-EGFP-IRES-creERT2 "knock-in" allele that both abolishes Lgr5 gene function and expresses EGFP and CreERT2 fusion protein. When these mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in the Lgr5-expressing cells of the offspring. These mice may be useful for lineage-tracing or marking Lgr5-expressing stem cells of the small intestine.

型号：GM-J#008870 -Cryorecovery

应用：These Hspa2-Cre mice have expression of Cre recombinase directed to the developing male germ cells by the mouse Hspa2 (heat shock protein 2 [Hsp70-2]) promoter. The Hspa2-Cre sequences of the transgene are flanked by Acrv1 (acrosomal vesicle protein 1 [SP-10]) insulator elements (which are believed to tether the Acrv1 gene to the nuclear matrix in somatic cells [preventing transcription]). When these transgenic mice are bred with mice containing a loxP-flanked sequence of interest, Cre-mediated recombination is expected to result in deletion of the floxed sequences in leptotene/zygotene spermatocytes of the male offspring. The donating investigator reports that expression of Hspa2-Cre may be "leaky" and recombination of loxP-flanked sequences can occur in some cells in somatic tissues. These Hspa2-Cre mice may be useful to generate conditional mutations for studying mammalian spermatocyte development, gametogenesis and meiosis.