型号：GM-J#023806 -Cryorecovery

应用：The CD19-Cre knockin/knockout allele has a Cre recombinase gene inserted into the first coding exon of the CD19 antigen gene (Cd19); both abolishing endogenous Cd19 gene function and placing cre expression under the control of the endogenous Cd19 promoter/enhancer elements. Cre recombinase expression is directed at the earliest stages and throughout B-lymphocyte development and differentiation. Homozygous mice are also useful for studying B cell-deficiency.

型号：GM-J#023748 -Available

应用：This transgenic strain expresses cre recombinase from the mouse Aldh1l1 (aldehyde dehydrogenase 1 family, member L1) promoter. This strain enables tissue-specific excision of floxed genomic segments in astrocytes as well as some oligodendrocytes and neurons.

型号：GM-J#023642 -Cryorecovery

应用：These tetO-AIMP2 mice may be useful for studying the Parkinson's disease pathogenesis and neurodegeneration elicited by the toxic effects of aggregation and somatic accumulation of AIMP2.

型号：GM-J#023598 -Cryorecovery

应用：These tetO-AIMP2 mice may be useful for studying the Parkinson's disease pathogenesis and neurodegeneration elicited by the toxic effects of aggregation and somatic accumulation of AIMP2.

型号：GM-J#023537 -Available

应用：ROSAnT-nG (also called nT/nG) is a nuclear-targeted, two-color fluorescent Cre reporter allele that express nuclear-localized red fluorescence in a widespread fashion prior to Cre recombinase exposure. Following exposure to Cre, nuclear-localized green fluorescence is observed.

型号：GM-J#023532 -Cryorecovery

应用：Ai82(TITL-EGFP)-D (also called Ai82D) mice are a Cre/Tet-dependent, fluorescent reporter line, created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). After removal of the floxed-STOP cassette by Cre recombinase, they may be used to generate Tet-Off/Tet-On mutant animals with conditional (inducible/reversible) expression of EGFP.

型号：GM-J#023531 -Cryorecovery

应用：Calb1-2A-dgCre-D (or Calb1-T2A-dgCre-D) mice express a trimethoprim-inducible EGFP/Cre fusion gene directed by endogenous calbindin 1 promoter/enhancer elements. When induced, small-to-moderately increased Cre recombinase activity is directed at high levels to scattered cells of the cortex, hippocampus, cerebellum and striatum, and restricted cell populations in thalamus and hypothalamus.

型号：GM-J#023530 -Available

应用：AVP-IRES2-Cre-D knockin mice have Cre recombinase expression directed to vasopressin-expressing cells (restricted populations within the hypothalamus). These mice may be useful for studying the function of antidiuretic hormone in water, glucose and salt homeostasis, as well as social behavior, sexual motivation and bonding, and maternal responses to stress.

型号：GM-J#023529 -Cryorecovery

应用：Ai79(TITL-Jaws)-D (also called Ai79D) mice are a Cre/Tet-dependent, optogenetic line, created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). Following Cre-mediated removal of the STOP cassette, they may be used to generate Tet-Off/Tet-On mutant animals with conditional (inducible/reversible) expression of an improved Halorhodopsin/EGFP fusion protein (Halo57*K200R*W214F/EGFP or Jaws). Subsequent illumination of Jaws-expressing (EGFP fluorescent) cells with yellow-to-red light leads to reversible photoinhibition of action potential firing/neural activity in these cells.

型号：GM-J#023528 -Cryorecovery

应用：Ai78(TITL-VSFPB)-D (also called Ai78D) mice are a Cre/Tet-dependent, voltage-sensitive, fluorescent line, created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). After removal of the floxed-STOP cassette by Cre recombinase, they may be used to generate Tet-Off/Tet-On mutant animals with conditional (inducible/reversible) expression of the voltage-sensitive fluorescent protein Butterfly 1.2 (VSFP-Butterfly1.2 or VSFPB1.2). VSFP-Butterfly1.2 exhibits voltage-dependent FRET upon membrane depolarization, and enables optical recordings at high spatial resolution with intrinsic assignment of recorded signals to VSFP-targeted cell populations (such as layer 2/3 pyramidal cells).