型号：GM-J#024098 -Available

应用：GFAP-Cre transgenic mice from founder line 77.6 have Cre recombinase expression directed to astrocytes in the brain and spinal cord by the mouse glial fibrillary acidic protein promoter. These GFAP-Cre line 77.6 mice may be useful for studying astrocytes in the brain and spinal cord.

型号：GM-J#024046 -Available

应用：These transgenic mice carry a BAC encoding a diphtheria toxin receptor-mCherry fusion protein (DTR-mCherry) preceded by a loxP-flanked transcriptional Stop element under the control of the Csf1r promoter. They are part of a two-gene approach to target monocytes and macrophages, but not conventional dendritic cells (cDCs).

型号：GM-J#024034 -Cryorecovery

应用：These Tg(Pmch-cre) mice have the pro-melanin-concentrating hormone promoter directing expression of a cre coding sequence in lateral hypothalamus melanin-concentrating hormone neurons.

型号：GM-J#023973 -Cryorecovery

应用：Ngn3-Cre mice express Cre Recombinase in all endocrine cell types in the pancreatic islet. When bred with a mouse containing a loxP site-flanked sequence of interest, Cre-mediated recombination results in deletion of the flanked gene in neurogenin 3 expressing tissues.

型号：GM-J#023972 -Cryorecovery

应用：When these RIP-CreER mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in pancreatic beta cells. This mutant mouse strain may be useful in studying pancreatic development, diabetes and obesity.

型号：GM-J#023968 -Cryorecovery

应用：This triple knockout strain is useful in studies of dopaminergic neuron physiology, regulation of striatal dopamine and serotonin, and Parkinson's disease.

型号：GM-J#023844 -Cryorecovery

应用：This knock-in, 2 kb 5' of the Ubb (ubiquitin B) gene, gives constitutive expression of a nuclear-localized beta-galactosidase/neomycin resistance protein reporter (NLS-beta-geo) in the absence of cre-mediated recombination. Following cre-mediated recombination, the NLS-beta-geo coding region is excised and the downstream triple HA epitope (3HA) tagged Fzd6 (frizzled homolog 6 (Drosophila)) coding region is expressed.

型号：GM-J#023843 -Cryorecovery

应用：This knock-in line at the Gt(ROSA)26Sor (gene trap ROSA 26, Philippe Soriano) locus gives no expression of triple hemagglutinin (HA) epitope-tagged Fzd6 (frizzled homolog 6 (Drosophila)) in the absence of cre-mediated recombination. Following cre-mediated recombination, a loxP-stop-loxP cassette is excised and the downstream triple HA epitope-tagged Fzd6 coding region is expressed, driven by the Gt(ROSA)26Sor promoter.

型号：GM-J#023841 -Cryorecovery

应用：This knock-in, 2 kb 5' of the Ubb (ubiquitin B) gene, gives constitutive expression of a nuclear-localized beta-galactosidase/neomycin resistance protein reporter (NLS-beta-geo) in the absence of cre-mediated recombination. Following cre-mediated recombination, the NLS-beta-geo coding region is excised and the downstream triple HA epitope (3HA) tagged Fzd3 (frizzled homolog 3 (Drosophila)) coding region is expressed.

型号：GM-J#023837 -Available

应用：These SNCA-OVX mice express a transgene containing the human SNCA gene and develop age-dependent motor incoordination and loss of nigrostriatal dopamine neurons. They are suitable for use in applications related to the study of Parkinson disease.