型号：GM-J#022976 -Cryorecovery

应用：GT11ML (MADM-ML-11GT) mice are designed for MADM (mosaic analysis with double markers), and must be crossed to mice harboring a reciprocal mutation at the same locus (TG11ML; Stock No. 022977). Compared to the single loxP approach of the original MADM designs, the multiple self-recognizing lox variant sites present in the MADM-ML system result in significantly improved recombination efficiency (4-8 fold higher) with no negative impact on G2-X segregation percentage (G2-X segregation produces the desired fluorescent homozygous mutant daughter cells). This MADM-ML system allows Cre recombinase-induced fluorescent labeling of daughter cells to ascertain lineal relationships and pleiotropic gene function in multicellular organisms. These mice may also be useful in studies of cell differentiation, mitosis, and imprinting.

型号：GM-J#022887 -Cryorecovery

应用：These Six6-cre transgenic mice may be useful for generating conditional mutations for studying craniofacial development.

型号：GM-J#022883 -Cryorecovery

应用：These Six6-cre transgenic mice may be useful for generating conditional mutations for studying craniofacial development.

型号：GM-J#022880 -Cryorecovery

应用：These Lrrk1 knock-out mice may be useful for studying the role of Lrrk1 in the progression of Parkinson's Disease.

型号：GM-J#022865 -Cryorecovery

应用：Trib2-2A-CreERT2-D knockin/knockout mice express an inducible CreERT2 fusion protein from the endogenous tribbles homolog 2 promoter/enhancer elements. When induced, cre activity is observed in superficial layer 5 cortical neurons, other scattered cells throughout the cortex, and brain vasculature. Disruption of the Trib2 gene is presumed.

型号：GM-J#022864 -Cryorecovery

应用：Rasgrf2-2A-dCre mice express a trimethoprim-inducible Cre recombinase directed by endogenous Rasgrf2 promoter/enhancer elements. When induced, Cre recombinase activity is observed in cortical layers 2/3 and other scattered cells of the cortex, hypothalamus, thalamus, and midbrain.

型号：GM-J#022863 -Cryorecovery

应用：Pvalb-T2A-dCre-D (Pvalb-2A-dCre-D) mice express a trimethoprim-inducible Cre recombinase directed to Pvalb-expressing cells by the endogenous promoter/enhancer elements of the parvalbumin locus. When induced, Cre recombinase activity is observed in scattered cells throughout the cortex, as well as restricted populations in the cerebellum, medulla, pons, pallidum, and thalamus.

型号：GM-J#022862 -Cryorecovery

应用：These knockin mice express a tamoxifen-inducible cre recombinase from the endogenous promoter/enhancer elements of the preproenkephalin locus. When induced, cre activity is observed in the striatum, olfactory tubercle, and sparse cells in the dentate gyrus and cortex.

型号：GM-J#022861 -Cryorecovery

应用：These knockin mice express a tamoxifen-inducible cre recombinase from the endogenous promoter/enhancer elements of the neurexophilin 4 locus. When induced, cre activity is observed in cortical layer 6b neurons and other scattered small cells [possibly glia] throughout the cortex.

型号：GM-J#022793 -Cryorecovery

应用：These ROSA26-LRRK2 (R1441C) mice allow cre-inducible expression of the familial Parkinson's disease-associated R1441C missense mutant form of LRRK2, and may be useful for studying Parkinson's disease pathogenesis and neurodegeneration.