产品型号：GM-J#038073 -Cryorecovery

产品应用：PSD95-lox-Stop-lox-TimeSTAMP2 mice have a loxP-flanked STOP codon and the TimeSTAMP cassette replacing the endogenous STOP codon of the Dlg4 gene. The TimeSTAMP (Time-Specific Tagging for the Age Measurement of Proteins) cassette contains N- and C-terminal Venus fragments separated by a cis-cleaving hepatitis C virus (HCV) NS3 protease, and a 2xHA-tag, expression of which is blocked by the presence of a loxP-flanked STOP cassette. After Cre induction, deletion of the STOP cassette allows the expression of PSD95-TimeSTAMP after administration of the NS3 inhibitor drug asunaprevir (ASV). This strain is useful for visualizing newly synthesized PSD95 where preservation of normal neuronal function is required.