型号：GM-J#038998 -Available For Pre-Order

应用：DBA/2J-OMM-GFP congenic mice were generated through repeated crosses of MitoTag (Rosa26-CAG-LSL-GFP-OMM; Stock No. 032675) animals to inbred DBA/2J mice (Stock No. 000671). The DBA/2J background of this line has made it particularly useful in studies of glaucoma.

型号：GM-J#038988 -Available For Pre-Order

应用：DAT-Cre MCUfl mice, based on a compound mutant strain described in Zampese, 2022 (PMID:36179023), were generated through an intercross of mice carrying an allele of the mouse Mcu (mitochondrial calcium uniporter) gene in which exons 5 and 6 are flanked by loxP sites (Stock No. 029817) with DATIREScre animals that direct Cre recombinase expression to dopaminergic neurons without disrupting endogenous dopamine transporter expression (Slc6a3tm1.1(cre)Bkmn; Stock No. 006660). Cre-mediated excision of the floxed region results in a knock-out of Mcu in dopaminergic neurons, useful in studies of Parkinson's disease (PD).

型号：GM-J#038959 -Available For Pre-Order

应用：Slc17a8-IRES2-Cre-neo knock-in mice have Cre recombinase expression directed to Vglut3-expressing cells, without disrupting endogenous vesicular glutamate transporter 3 expression. These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping related to glutamatergic synaptic vesicle trafficking.

型号：GM-J#038958 -Available For Pre-Order

应用：Rorb-IRES2-Cre-neo knock-in mice have Cre recombinase expression directed to Rorb-expressing cells, without disrupting endogenous RAR-related orphan receptor beta expression. These mice may be useful for studying this nuclear hormone receptor/DNA-binding protein in hormone-responsive gene expression and behavior.

型号：GM-J#038957 -Cryorecovery

应用：Cartpt-IRES2-Cre-neo knock-in mice have Cre recombinase expression directed to CART prepropeptide-expressing cells, without disrupting endogenous Cartpt expression. These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping in subgroups of brain tissues (including cortex, cerebral nuclei, hypothalamus and midbrain) in regards to feeding, appetite and stress response, as well as gene regulation by cocaine and other drugs.

型号：GM-J#038956 -Cryorecovery

应用：Npr3-IRES2-CreERT2-neo knock-in mice are designed to have cre/ERT2 expression/activity directed by the endogenous natriuretic peptide receptor 3 promoter/enhancer sequences. In the brain, cre/ERT2 expression is observed to be enriched in cortical layer 5 and in restricted cell populations within the hippocampal formation. These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping in NPR3-expressing cells.

型号：GM-J#038955 -Cryorecovery

应用：Npr3-IRES2-Cre-neo knock-in mice are designed to have Cre recombinase expression/activity directed by the endogenous natriuretic peptide receptor 3 promoter/enhancer sequences. In the brain, Cre expression is observed to be enriched in cortical layer 5 and in restricted cell populations within the hippocampal formation. These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping in NPR3-expressing cells.

型号：GM-J#038954 -Cryorecovery

应用：Vipr2-IRES2-Cre-neo knock-in mice are designed to have Cre recombinase expression/activity directed by the endogenous vasoactive intestinal peptide receptor 2 promoter/enhancer sequences. In the brain, it is observed in arcuate hypothalamic nucleus, dorsal lateral geniculate nucleus, ventral nucleus of the thalamus and bed nuclei of the stria terminalis, with scattered expression in superior colliculus and throughout the cortex. These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping in VIPR2-expressing cells.

型号：GM-J#038953 -Available For Pre-Order

应用：Chrna6-IRES2-FlpO-neo knock-in mice are designed to have optimized FLP recombinase expression directed to CHRNA6-expressing cells. FlpO expression/activity is observed in many locations throughout brain, with sparse labeling in Layer 5ET and none in Layer 6b. These mice may be used to generate conditional mutations for studying α6-containing nicotinic acetylcholine receptors, for example, the role of dopaminergic neurons in nicotine addiction or as a possible therapeutic target for Parkinson's disease treatment.

型号：GM-J#038896 -Available For Pre-Order

应用：MBP hα-syn Line 29 transgenic mice express wildtype human α-synuclein cDNA driven by the mouse Mbp promoter. These mice may be useful in studying human neuronal α-synucleinopathies, such as multiple systems atrophy (MSA).