型号：GM-J#039156 -Available For Pre-Order

应用：Zic5-CreER knock-in/knock-out mice express a CreER fusion protein driven by the zinc finger protein of the cerebellum 5 (Zic5) endogenous promoter while abolishing endogenous Zic5 expression. When bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible Cre-mediated recombination will result in the deletion of the floxed sequences in the Zic5-expressing cells of the offspring. These mice may be useful when studying the fate of pre-migratory neural crest cells.

型号：GM-J#039125 -Available For Pre-Order

应用：Gpr17-Cre mice constitutively express Cre recombinase from the mouse G protein-coupled receptor 17 (Gpr17) promoter in CNS cells of the oligodendrocyte lineage and a subset of astrocytes when recombination is induced embryonically. Expression of the targeted Gpr17 gene is not affected by the knock-in.

型号：GM-J#039034 -Available For Registering Interest

应用：This quadruple Htra knock-out has deletions in Htra1 exons 2-3, Htra2 exons 2-4, Htra3 exon 3, and Htra4 exons 4-6. This strain may be useful in studies of age-related diseases including Parkinson's disease and age-related macular degeneration.

型号：GM-J#039032 -Available For Registering Interest

应用：Htra2flox mice possess loxP sites flanking exons 2-4 of the Htra2 (HtrA serine peptidase 2) gene. These floxed mice are useful for tissue specific deletion of Htra2 in studies of neurodegeneration, mitochondrial integrity, and Parkinson's disease.

型号：GM-J#039022 -Available For Pre-Order

应用：Tacr1CreERT2 knock-in/knock-out mice express tamoxifen-inducible Cre recombinase from the mouse tachykinin receptor 1 (Tacr1) promoter in Tacr1-expressing cells of the spinal cord and brain, including spinal projection neurons of the anterolateral pathway. This strain may be useful in studies of nociception (pain and affective touch).

型号：GM-J#039021 -Cryorecovery

应用：Gpr83CreERT2 knock-in/knock-out mice express tamoxifen-inducible Cre recombinase from the mouse G protein-coupled receptor 83 (Gpr83) promoter in Gpr83-expressing cells of the spinal cord and brain, including spinal projection neurons of the anterolateral pathway. This strain may be useful in studies of nociception (pain and affective touch).

型号：GM-J#039016 -Available For Pre-Order

应用：NOD.B10Cre-Vav transgenic mice have the mouse HS21/45 control regions directing expression of an optimized variant of Cre recombinase (iCre) to hematopoietic cells (and their progenitors), on a NOD.B10 genetic background (Stock No. 002591). This congenic strain has the MHC H2b haplotype from the C57BL/10SnJ strain with mice exhibiting some but not all of the immune dysfunctions of NOD/LtJ (Stock No. 001976) mice. These mice may be useful for generating conditional mutations in hematopoietic cells.

型号：GM-J#039008 -Available For Pre-Order

应用：Rosa26LSL-DPR dual pathway reporter (DPR) mice conditionally express fluorescent Erk kinase translocation reporter (Erk-KTR/mTagBFP2), a fluorescent histone 2B chromatin/nucleus tag (H2B/iRFP713), and the N-terminal regulatory domain of Nfatc2 fused to the mRuby3 reporter (Nfatc2/mRuby3) from the Gt(ROSA)26Sor locus enabling live-cell in vivo studies of T cell receptor signaling pathway dynamics.

型号：GM-J#039003 -Available For Registering Interest

应用：FLIM-compatible A Kinase Activity Reporter (FL-AK, FLIM-AKARflox) mice express the FLIM-AKAR optical fluorescent reporter in a Cre-dependent manner. Cre recombinase-mediated excision of a loxP-flanked Stop cassette enables the observation of protein kinase A (PKA) activity with cellular resolution in real time. This strain has been useful in revealing PKA activity dynamics in genetically defined cell types via fluorescence lifetime imaging microscopy (FLIM) or photometry in brain slices and in vivo.

型号：GM-J#038999 -Available For Pre-Order

应用：DBA/2J-VGlut2-Cre congenic mice were generated through repeated crosses of Vglut2-ires-cre knock-in (C57BL/6J) (Stock No. 028863) animals to inbred DBA/2J mice (Stock No. 000671). The DBA/2J background of this line has made it particularly useful in studies of glaucoma.