型号：GM-J#043926-JAX -Cryorecovery

应用：Rosa26-LSL-dCas9 mice (Gt(ROSA)26Sortm1(CAG-dCas9-SunTag)Khk) are a Cre-inducible CRISPR/Cas9 activation (CRISPRa) tool for cell type specific gene activation in vivo.

型号：GM-J#043846-JAX -Cryorecovery

应用：ProkR2-Cre knock-in mice are designed to have codon optimized iCre recombinase expression directed to prokineticin receptor 2-expressing cells. These mice may be used to generate conditional mutations for studying gonadotropin-releasing hormone neuronal migration, olfactory bulb development, infertility, and Kallmann syndrome.

型号：GM-J#043796-JAX -Cryorecovery

应用：These BAC transgenic mice express Cre recombinase from the mouse Dcdc2a gene (doublecortin domain containing 2a). Recombination has been observed in ependymal cells lining the ventricle of the brain, the choroid plexus, and tanycytes in the third ventricle.

型号：GM-J#043695-JAX -Cryorecovery

应用：These BAC transgenic mice express Cre recombinase from the mouse Cbln1 (cerebellin 1 precursor protein) gene. Recombination has been observed in mitral neurons in the olfactory bulb, projection neurons in the entorhinal cortex and granule neurons in the cerebellum.

型号：GM-J#042277-JAX -Cryorecovery

应用：These Gcg-CreERT2 mice have Cre-ERT2 knocked into the 3' UTR region of the glucagon gene (Gcg). Inducible Cre expression is observed in pancreatic alpha cells and endocrine L cells.

型号：GM-J#041504-JAX -Cryorecovery

应用：These CRE3 transgenic mice express Cre recombinase under the control of the rat myosin light chain II ventricular (Mylpf or MLC2v) promoter beginning at E11.5 in the brain. This strain may be useful for generating conditional deletions in neurons and their progenitors.

型号：GM-J#039341 -Available For Registering Interest

应用：EKLF-CRE CRISPR-derived knock-in mice are designed to have T2A self-cleaving peptide fused to an iCre sequence inserted in-frame into the C-terminal of the Klf1 gene. The endogenous Klf1 promoter directs expression of iCre recombinase to tissues in the early developing embryo as well as in adult bone marrow. These mice are useful for studying and tracing the maturation of erythroid cells.

型号：GM-J#039267 -Available For Registering Interest

应用：TIGRE2-RiboL1-jGCaMP8s-IRES-tTA2 knock-in mice co-express a fusion of jGCaMP8s genetically encoded calcium indicator (GECI) tethered to a component of the large ribosomal subunit (Rpl10) via an optimized linker sequence (L1) and a tetracycline-controlled transactivator (tTA2) in a Cre recombinase-dependent manner from the intergenic Igs7 (TIGRE) locus. By tethering jGCaMP8s to the ribosome, protein expression is restricted to the cell soma thereby reducing neuropil signals. The addition of an internal ribosome entry site (IRES) introduced upstream of tTA and the omission of a WPRE enhancer element downstream ameliorate previously reported tTA overexpression toxicity issues. jGCaMP8s is a fast rise, medium decay green fluorescent-based GECI with improved sensitivity and faster kinetics.

型号：GM-J#039261 -Available For Registering Interest

应用：Ntrk22A-Cre knock-in (KI) mice express a Cre recombinase (Cre) driven by the Ntrk2 endogenous promoter, while retaining endogenous expression of the full length tropomyosin related kinase receptor B (TrkB.FL). When these mice are bred with mice containing a loxP-flanked sequence of interest, Cre-mediated recombination will result in deletion of the floxed sequences in the Ntrk2-expressing cells of the offspring. These mice may be useful for studying the role of TrkB.FL in neurogenesis and synaptic plasticity.

型号：GM-J#039260 -Available For Registering Interest

应用：BdnfNLuc knock-in mice contain a CRISPR/Cas9 generated insertion of a NanoLuciferase (NLuc) immediately before the stop codon of the Bdnf gene. These mice may be useful when studying the role of BDNF in neuronal development and survival, synaptic plasticity, and cognitive function.