型号：GM-J#039236 -Available For Registering Interest

应用：These NoGlow mice selectively express antigen-intact but non-functional forms of GFP and luciferase, as well as a non-mutated rtTA3, after Cre-mediated recombination. NoGlow mice are a GFP and luciferase tolerant mouse model that allows engraftment, tracking, and tetracycline-inducible gene expression. NoGlow mice provide a critical resource for in vivo studies across multiple disciplines, including oncology, developmental biology, infectious disease, autoimmunity, and transplantation.

型号：GM-J#039218 -Available For Pre-Order

应用：CRISPR/Cas9 generated Slc47a1-creERT2 knock-in mice have cre-ERT2-P2A inserted between exon 16 and the 3' UTR of the Slc47a1 gene. They are useful for applications requiring tamoxifen-induced deletion of floxed sequences in dural border cells (DBCs) of the brain and when studying the blood-cerebrospinal fluid barrier.

型号：GM-J#039217 -Available For Pre-Order

应用：CRISPR/Cas9 generated Dpp4-creERT2 knock-in mice have cre-ERT2-P2A inserted between the 5' UTR and exon 1 of the Dpp4 gene. They are useful for applications requiring tamoxifen-induced deletion of floxed sequences in arachnoid barrier cells (ABCs) of the brain and when studying the blood-cerebrospinal fluid barrier.

型号：GM-J#039205 -Available For Registering Interest

应用：Neurog1C-CreKI mice have a C-terminal Cre recombinase fragment (C-Cre) replacing the entire Neurog1 coding region. When bred with another strain expressing a N-Cre, the resulting N-Cre and C-Cre co-expression reconstitutes a functional Cre recombinase enzyme complex in neural progenitor cells (NPCs).

型号：GM-J#039203 -Available For Registering Interest

应用：Neurog2N-CreKI mice have an N-terminal Cre recombinase fragment (N-Cre) replacing the entire Neurog2 coding region. When bred with another strain expressing a C-Cre, the resulting N-Cre and C-Cre co-expression reconstitutes a functional Cre recombinase enzyme complex in neural progenitor cells (NPCs).

型号：GM-J#039195 -Available For Registering Interest

应用：Il17Cre knock-in mice express a EYFP/Cre recombinase fusion protein, while retaining endogenous Il17a expression. These mice may be useful for fate mapping IL17A secretion during T helper cell activation.

型号：GM-J#039188 -Available For Pre-Order

应用：Aif1-IRES-Cre knock-in mice express Cre recombinase under the direction of the Aif1 promoter in microglia in the adult brain. These mice are suitable for use in applications related to functional imaging of activity in neurons and microglia.

型号：GM-J#039168 -Available For Pre-Order

应用：Humanized E46K SNCA-GR (gene replacement) mice are a knock-in/knock-out model in which the mouse genomic region from Snca (synuclein, alpha) is exchanged for 158 kb of the human SNCA genomic region including the E46K mutation. E46K is associated with Parkinson's disease (PD). This strain may be used to explore more fully the role of SNCA in Parkinson's disease (PDD), dementia with Lewy bodies (DLB), multiple system atrophy (MSA), and Alzheimer's disease.

型号：GM-J#039167 -Available For Pre-Order

应用：Humanized A53T SNCA-GR (gene replacement) mice are a knock-in/knock-out model in which the mouse genomic region from Snca (synuclein, alpha) is exchanged for 158 kb of the human SNCA genomic region including the A53T mutation. A53T is associated with early-onset Parkinson's disease (PD). This strain may be used to explore more fully the role of SNCA in Parkinson's disease (PDD), dementia with Lewy bodies (DLB), multiple system atrophy (MSA), and Alzheimer's disease.

型号：GM-J#039166 -Available For Pre-Order

应用：Humanized wildtype SNCA-GR (gene replacement) mice are a knock-in/knock-out model in which the mouse genomic region from Snca (synuclein, alpha) is exchanged for 158 kb of the human SNCA genomic region. These mice may serve as base models into which additional alterations can be introduced to explore more fully the role of SNCA in Parkinson's disease (PDD), dementia with Lewy bodies (DLB), multiple system atrophy (MSA), and Alzheimer's disease.