型号：GM-J#023530 -Available

应用：AVP-IRES2-Cre-D knockin mice have Cre recombinase expression directed to vasopressin-expressing cells (restricted populations within the hypothalamus). These mice may be useful for studying the function of antidiuretic hormone in water, glucose and salt homeostasis, as well as social behavior, sexual motivation and bonding, and maternal responses to stress.

型号：GM-J#023529 -Cryorecovery

应用：Ai79(TITL-Jaws)-D (also called Ai79D) mice are a Cre/Tet-dependent, optogenetic line, created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). Following Cre-mediated removal of the STOP cassette, they may be used to generate Tet-Off/Tet-On mutant animals with conditional (inducible/reversible) expression of an improved Halorhodopsin/EGFP fusion protein (Halo57*K200R*W214F/EGFP or Jaws). Subsequent illumination of Jaws-expressing (EGFP fluorescent) cells with yellow-to-red light leads to reversible photoinhibition of action potential firing/neural activity in these cells.

型号：GM-J#023528 -Cryorecovery

应用：Ai78(TITL-VSFPB)-D (also called Ai78D) mice are a Cre/Tet-dependent, voltage-sensitive, fluorescent line, created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). After removal of the floxed-STOP cassette by Cre recombinase, they may be used to generate Tet-Off/Tet-On mutant animals with conditional (inducible/reversible) expression of the voltage-sensitive fluorescent protein Butterfly 1.2 (VSFP-Butterfly1.2 or VSFPB1.2). VSFP-Butterfly1.2 exhibits voltage-dependent FRET upon membrane depolarization, and enables optical recordings at high spatial resolution with intrinsic assignment of recorded signals to VSFP-targeted cell populations (such as layer 2/3 pyramidal cells).

型号：GM-J#023527 -Cryorecovery

应用：The C57BL/6J-congenic Slc17a7-IRES2-Cre-D strain is available as Stock No. 037512. The B6;129S background Slc17a7-IRES2-Cre-D strain (Stock No. 023527) is available via cryo recovery.

型号：GM-J#023526 -Cryorecovery

应用：Rorb-IRES2-Cre-D knockin mice have Cre recombinase expression directed to Rorb-expressing cells, without disrupting endogenous RAR-related orphan receptor beta expression. These mice may be useful for studying this nuclear hormone receptor/DNA-binding protein in hormone-responsive gene expression and behavior.

型号：GM-J#023525 -Cryorecovery

应用：Snap25-IRES2-Cre-D knockin mice have widespread Cre recombinase expression directed throughout the brain, without disrupting endogenous synaptosomal-associated protein 25 expression. These mice may be useful for studying t-SNARE proteins and synaptic vesicle/plasma membrane fusion.

型号：GM-J#023453 -Cryorecovery

应用：These Lhx8cre/cerulean mice express cre recombinase and the cerulean variant of green fluorescent protein (GFP) driven by the endogenous LIM homeobox protein 8 promoter/enhancer elements. They may be useful for generating conditional mutations for studying craniofacial development.

型号：GM-J#023451 -Cryorecovery

应用：These transgenic mice express human CD4 and CCR5 under the regulatory control of the human ubiquitin C promoter in combination with a widely-expressed luciferase reporter regulated by the Gt(ROSA)26Sor promoter. The mice enable the rapid measurement of HIV-1 transmission by peritoneal and genitomucosal HIV-1 pseudovirus entry in vivo. The system represents a model for the pre-clinical evaluation of prophylactic or vaccine candidates.

型号：GM-J#023428 -Cryorecovery

应用：This mouse strain features a Cre-inducible luciferase reporter gene inserted into exon 2 of the mouse Cdkn1a gene, knocking out expression. Cre-mediated excision of a floxed stop segment enables tissue-specific expression of luciferase under the direction of the endogenous Cdkn1a promoter.

型号：GM-J#023426 -Cryorecovery

应用：This Kiss1-Cre transgenic line expresses Cre recombinase in Kiss1 (kisspeptin) expressing cells and neurons and has applications in studies of the gonadotropic axis regulation and reproductive function.