型号：GM-J#023843 -Cryorecovery

应用：This knock-in line at the Gt(ROSA)26Sor (gene trap ROSA 26, Philippe Soriano) locus gives no expression of triple hemagglutinin (HA) epitope-tagged Fzd6 (frizzled homolog 6 (Drosophila)) in the absence of cre-mediated recombination. Following cre-mediated recombination, a loxP-stop-loxP cassette is excised and the downstream triple HA epitope-tagged Fzd6 coding region is expressed, driven by the Gt(ROSA)26Sor promoter.

型号：GM-J#023841 -Cryorecovery

应用：This knock-in, 2 kb 5' of the Ubb (ubiquitin B) gene, gives constitutive expression of a nuclear-localized beta-galactosidase/neomycin resistance protein reporter (NLS-beta-geo) in the absence of cre-mediated recombination. Following cre-mediated recombination, the NLS-beta-geo coding region is excised and the downstream triple HA epitope (3HA) tagged Fzd3 (frizzled homolog 3 (Drosophila)) coding region is expressed.

型号：GM-J#023837 -Available

应用：These SNCA-OVX mice express a transgene containing the human SNCA gene and develop age-dependent motor incoordination and loss of nigrostriatal dopamine neurons. They are suitable for use in applications related to the study of Parkinson disease.

型号：GM-J#023806 -Cryorecovery

应用：The CD19-Cre knockin/knockout allele has a Cre recombinase gene inserted into the first coding exon of the CD19 antigen gene (Cd19); both abolishing endogenous Cd19 gene function and placing cre expression under the control of the endogenous Cd19 promoter/enhancer elements. Cre recombinase expression is directed at the earliest stages and throughout B-lymphocyte development and differentiation. Homozygous mice are also useful for studying B cell-deficiency.

型号：GM-J#023748 -Available

应用：This transgenic strain expresses cre recombinase from the mouse Aldh1l1 (aldehyde dehydrogenase 1 family, member L1) promoter. This strain enables tissue-specific excision of floxed genomic segments in astrocytes as well as some oligodendrocytes and neurons.

型号：GM-J#023642 -Cryorecovery

应用：These tetO-AIMP2 mice may be useful for studying the Parkinson's disease pathogenesis and neurodegeneration elicited by the toxic effects of aggregation and somatic accumulation of AIMP2.

型号：GM-J#023598 -Cryorecovery

应用：These tetO-AIMP2 mice may be useful for studying the Parkinson's disease pathogenesis and neurodegeneration elicited by the toxic effects of aggregation and somatic accumulation of AIMP2.

型号：GM-J#023537 -Available

应用：ROSAnT-nG (also called nT/nG) is a nuclear-targeted, two-color fluorescent Cre reporter allele that express nuclear-localized red fluorescence in a widespread fashion prior to Cre recombinase exposure. Following exposure to Cre, nuclear-localized green fluorescence is observed.

型号：GM-J#023532 -Cryorecovery

应用：Ai82(TITL-EGFP)-D (also called Ai82D) mice are a Cre/Tet-dependent, fluorescent reporter line, created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). After removal of the floxed-STOP cassette by Cre recombinase, they may be used to generate Tet-Off/Tet-On mutant animals with conditional (inducible/reversible) expression of EGFP.

型号：GM-J#023531 -Cryorecovery

应用：Calb1-2A-dgCre-D (or Calb1-T2A-dgCre-D) mice express a trimethoprim-inducible EGFP/Cre fusion gene directed by endogenous calbindin 1 promoter/enhancer elements. When induced, small-to-moderately increased Cre recombinase activity is directed at high levels to scattered cells of the cortex, hippocampus, cerebellum and striatum, and restricted cell populations in thalamus and hypothalamus.