型号：GM-J#024103 -Cryorecovery

应用：Ai93(TITL-GCaMP6f)-D (also called Ai93D) mice are a Cre/Tet-dependent, fluorescent calcium indicator line, created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). After removal of the floxed-STOP cassettes by Cre recombinase, they may be used to generate Tet-Off/Tet-On mutant animals with conditional (inducible/reversible) expression of GCaMP6 fast variant calcium indicator (GCaMP6f; a detector of single neuronal action potentials with fast response kinetics). Following subsequent calcium binding (such as neuronal activation), bright EGFP fluorescence is observed.

型号：GM-J#024101 -Cryorecovery

应用：The interleukin 1 type I receptor restore allele (IL-1R1r) is a functional null prior to Cre recombinase exposure. These mice allow Cre recombinase-inducible restoration of functional IL-1R1 expression, and visualization of IL-1R1-expressing cells with concordant labeling of IL-1R1 mRNA (by tdTomato fluorescence) and protein (by 3xHA epitope). IL-1R1r mice may be useful for studying cell-type-specific functions of IL-1R1 in neuroimmunity and neuroinflammation.

型号：GM-J#024100 -Cryorecovery

应用：Ai90(TITL-Chronos)-D (also called Ai90D) mice are a Cre/Tet-dependent, optogenetic line, created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). Following Cre-mediated removal of the STOP cassette, they may be used to generate Tet-Off/Tet-On mutant animals with conditional (inducible/reversible) expression of the channelrhodopsin/EGFP fusion protein (Chronos/EGFP). Subsequent illumination of Chronos-expressing (EGFP fluorescent) cells with blue-to-green light leads to reversible photostimulation of action potential firing/neural activity in these cells.

型号：GM-J#024098 -Available

应用：GFAP-Cre transgenic mice from founder line 77.6 have Cre recombinase expression directed to astrocytes in the brain and spinal cord by the mouse glial fibrillary acidic protein promoter. These GFAP-Cre line 77.6 mice may be useful for studying astrocytes in the brain and spinal cord.

型号：GM-J#024046 -Available

应用：These transgenic mice carry a BAC encoding a diphtheria toxin receptor-mCherry fusion protein (DTR-mCherry) preceded by a loxP-flanked transcriptional Stop element under the control of the Csf1r promoter. They are part of a two-gene approach to target monocytes and macrophages, but not conventional dendritic cells (cDCs).

型号：GM-J#024034 -Cryorecovery

应用：These Tg(Pmch-cre) mice have the pro-melanin-concentrating hormone promoter directing expression of a cre coding sequence in lateral hypothalamus melanin-concentrating hormone neurons.

型号：GM-J#023973 -Cryorecovery

应用：Ngn3-Cre mice express Cre Recombinase in all endocrine cell types in the pancreatic islet. When bred with a mouse containing a loxP site-flanked sequence of interest, Cre-mediated recombination results in deletion of the flanked gene in neurogenin 3 expressing tissues.

型号：GM-J#023972 -Cryorecovery

应用：When these RIP-CreER mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in pancreatic beta cells. This mutant mouse strain may be useful in studying pancreatic development, diabetes and obesity.

型号：GM-J#023968 -Cryorecovery

应用：This triple knockout strain is useful in studies of dopaminergic neuron physiology, regulation of striatal dopamine and serotonin, and Parkinson's disease.

型号：GM-J#023844 -Cryorecovery

应用：This knock-in, 2 kb 5' of the Ubb (ubiquitin B) gene, gives constitutive expression of a nuclear-localized beta-galactosidase/neomycin resistance protein reporter (NLS-beta-geo) in the absence of cre-mediated recombination. Following cre-mediated recombination, the NLS-beta-geo coding region is excised and the downstream triple HA epitope (3HA) tagged Fzd6 (frizzled homolog 6 (Drosophila)) coding region is expressed.