型号：GM-J#023409 -Cryorecovery

应用：These mutant mice express the D620N mutation in exon 15 of the Vps35 (VPS35 retromer complex component) gene. VPS35 D620N KI mice recapitulate many of the characteristics of Parkinson's disease including neurodegeneration of DA neurons, accumulation of α-synuclein in DA neurons and age-dependent progressive motor deficits.

型号：GM-J#023407 -Cryorecovery

应用：These Creface transgenic mice have a cre-recombinase sequence driven by the human transcription factor AP-2, alpha promoter/enhancer elements, and a polyadenylation sequence followed by parts of exons 5-6 of Tfap2a, encoding the frontonasal prominence (FNP) and limb enhancer elements. This transgene integrated into intron 9 of the hedgehog acyltransferase (Hhat) gene, abolishing Hhat gene function. These mice may be useful for studying craniofacial development.

型号：GM-J#023342 -Cryorecovery

应用：These mice express muscle specific tamoxifen-inducible cre, and may be useful when evaluating embryonic muscle-specific cell lineage contributions to the adult satellite cell compartment.

型号：GM-J#023329 -Cryorecovery

应用：The p48-cre knock-in/knock-out allele has a Cre recombinase gene inserted into the first coding exon of the Ptf1a gene; both abolishing endogenous Ptf1a gene function and placing cre expression under the control of the endogenous Ptf1a promoter/enhancer elements. Cre recombinase activity occurs in the developing pancreas, neural tube, cerebellum, retina and male germline. These mice may be useful for Cre-lox studies of pancreatic development.

型号：GM-J#023325 -Cryorecovery

应用：These mice express Cre recombinase under the control of the composite rat probasin (Pbsn) promoter. This strain represents an effective tool for generating prostate specific-targeted mutants.

型号：GM-J#023203 -Cryorecovery

应用：These BAC transgenic mice express Cre recombinase under control of the Itgax gene (or Cd11c) promoter/enhancer regions within the BAC transgene. These Cd11c-Cre mice are suitable for use in the deletion of floxed sequences in CD8-, CD8+ dendritic cells, tissue-derived dendritic cells from lymph nodes, lung and epidermis, as well as plasmacytoid dendritic cells.

型号：GM-J#023201 -Cryorecovery

应用：PipGCE mice express an EGFP/Cre-ERT2 fusion protein in acinar cells of the neonatal and adult submandibular gland. These mice may have applications in studies requiring conditional gene manipulation in the submandibular gland, as well as for acinar cell lineage fate mapping.

型号：GM-J#023139 -Available

应用：R26 LSL H2B mCherry (Rosa26-CAG-LSL-H2B-mCherry) mutant mice have a loxP-flanked STOP sequence followed by an H2B-mCherry fusion protein inserted into the Gt(ROSA)26Sor locus. Cre inducible, nuclear expression of the mCherry protein allows the monitoring of Cre activity in living tissues and makes possible lineage tracing of such cells in embryos, young and adult mice at desired time points.

型号：GM-J#023055 -Cryorecovery

应用：Krt12-Cre mice expresses Cre recombinase from endogenous Krt12 promoter/enhancer elements. This strain represents an effective tool for generating corneal epithelia specific-targeted mutants.

型号：GM-J#023047 -Cryorecovery

应用：These mice express Cre recombinase under the control of the murine dentin matrix protein 1 (Dmp1) promoter/enhancer elements. This strain represents an effective tool for generating odontoblast and osteocyte specific-targeted mutants that would be useful in studies of bone growth and mineralization.