型号：GM-J#031799 -Cryorecovery

应用：Pbrm1lacZ mice express a β-galactosidase gene and are null for Pbrm1, in addition, exon 4 is flanked by loxP sites in this conditional knock-out-first strain. These mice may be useful in studies of clear cell renal carcinoma and von Hippel-Lindau syndrome.

型号：GM-J#031779 -Cryorecovery

应用：Cyp19a1-Cre BAC transgenic mice express cre recombinase from the mouse Cyp19a1 (aromatase) promoter, faithfully recapitulating brain expression patterns of the endogenous mouse gene.

型号：GM-J#031776 -Cryorecovery

应用：TB (tTA2-BFP) mice have a floxed-STOP cassette preventing transcription of the downstream genes - tTA2 (tetracycline-controlled transactivator) and mTagBFP (nuclear-targeted monomeric blue fluorescent protein). TB mice are useful for Cre-dependent Tet-Off applications, as well as a Cre-dependent fluorescent reporter tool strain.

型号：GM-J#031704 -Cryorecovery

应用：Ten3cre knock-in/knock-out mice express cre recombinase from the mouse Tenm3 (teneurin transmembrane protein 3) promoter.

型号：GM-J#031693 -Cryorecovery

应用：CAG-SUMO line 10 mice have widespread EGFP fluorescence that can be replaced by SUMO1/2/3 paralog expression and mCherry fluorescence after Cre recombinase exposure. These mice may be useful for studying in vivo SUMO proteomics - for example, mechanistically linking SUMO conjugation (SUMOylation) and the SUMO-modified proteome to the pathological processes of human disorders.

型号：GM-J#031679 -Cryorecovery

应用：TcrdCreER knock-in mice express tamoxifen-inducible Cre recombinase under the direction of the T cell receptor delta chain (Tcrd) promoter in γδ T cells. These mice are useful for lineage tracking and genetic manipulation of the tissue resident γδ T cells.

型号：GM-J#031674 -Cryorecovery

应用：When these LysM-Cre ERT2 knock-in/knock-out mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in myeloid cells. They are suitable for use in applications related to tamoxifen-inducible Cre-lox studies of the myeloid cell lineage (monocytes, mature macrophages and granulocytes) and the innate immune response.

型号：GM-J#031671 -Cryorecovery

应用：These GFAP.tTA.TRE.Flag.HMOX1 mice express human heme oxygenase 1 (HMOX1) in astrocytes under the control of the Tet-Off system (removal of doxycycline from diet initiates transgene expression), resulting in 1.4 to 5.8-fold increase in total of heme oxygenase 1 protein in astrocytes. Depending on the window of gene expression, these double transgenic mice exhibit inducible locomotor impairment, stereotypy, and mitochondrial damage & autophagy. They are suitable for use in applications related to the study of oxidative stress in the brain, neurodevelopment and neurodegenerative diseases.

型号：GM-J#031661 -Available

应用：ChAT-IRES-Cre knock-in mice express Cre recombinase in cholinergic neurons, without disrupting endogenous Chat expression. These mice may be useful in neurobiological research of motor function, learning and memory, Alzheimer's disease, and Down syndrome, as well as obesity and diabetes research.

型号：GM-J#031645 -Available

应用：Removal of this mouse colony is imminent. If live mice are needed for your studies, it is advised that they be ordered immediately. After removal, the mice will be available from a cryorecovery.