型号：GM-J#032536 -Available

应用：AdvillinCre knock-in/knock-out mice are useful for Cre recombinase expression in sensory neurons.

型号：GM-J#032489 -Cryorecovery

应用：These mice harbor a Wnt4GCE knock-in/knock-out allele that both abolishes Wnt4 gene function and expresses EGFP and creERT2 from the Wnt4 promoter/enhancer elements. While EGFP expression is observed in developing nephron tubules at 15.5 dpc, Cre-ERT2 fusion gene activity is observed in the same cells only following tamoxifen administration. These Wnt4GCE mice may be useful for lineage-tracing/marking Wnt4-expressing during kidney organogenesis.

型号：GM-J#032488 -Cryorecovery

应用：This Six2CE knock-in/knock-out allele was designed to both abolish expression of the Six2 gene and direct expression of the CreERT2 fusion protein from the Six2 promoter/enhancer elements. These mice are a Cre-lox tool that allows inducible Cre expression in Six2-expressing cells/tissues; including developing nephron progenitor cells.

型号：GM-J#032468 -Cryorecovery

应用：Trh-ires-Cre knock-in mice express Cre recombinase under direction of the thyrotropin releasing hormone promoter in the paraventricular hypothalamus making them useful for cell-specific neuron mapping.

型号：GM-J#032467 -Cryorecovery

应用：FSF-LSL-SypYFP (or R26-CAG-FSF-LSL-SypYFP) is a dual-recombinase intersectional allele that has a frt-flanked STOP and loxP-flanked STOP that prevent transcription of a synaptophysin-YFP fusion protein. Exposure to FLP recombinase and Cre recombinase results in YFP expression enriched at the synapse/synaptic vesicle (axonal boutons [terminal and en passant]) of the neuron subtype(s) defined by the overlap of FLP/Cre expression.

型号：GM-J#032457 -Cryorecovery

应用：LeprCre knock-in mice may be useful for studying leptin action and energy balance.

型号：GM-J#032456 -Cryorecovery

应用：Fbxo2VHC mice have a multicistronic reporter inserted into the ATG start codon of the F-box protein 2 (Fbxo2) gene. Specifically, this vector includes (from 5' to 3') an H2B-Venus fusion protein (coding sequence for the human HIST1H2BB gene [histone 1 H2bb] with a C-terminal yellow fluorescent protein sequence), a hygromycin resistance gene flanked with viral P2A oligopeptides, a cre/ERT2 fusion gene (Cre recombinase fused to a human estrogen receptor ligand binding domain), and a polyadenylation signal. Insertion of this reporter cassette abolishes Fbxo2 gene expression. These mice may be useful when studying inner ear sensory epithelial cells.

型号：GM-J#032453 -Cryorecovery

应用：STARS (STochastic gene Activation with Regulated Sparseness) knock-in mice express mCherry or Cre-dependent membrane bound YFP (meYFP). They are suitable for use in applications related to both CNS and PNS neural circuit mapping and sparse genetic manipulation, as well as visualization of the detailed morphology of other cell types.

型号：GM-J#032429 -Available Now

应用："KPC, tamoxifen-inducible" is a KrasLSL-G12D;p53LoxP;Pdx1-CreER triple mutant model of tamoxifen-inducible pancreatic ductal adenocarcinoma (PDAC).

型号：GM-J#032301 -Cryorecovery

应用：R26-LSL-SOUL-P2A-tdT mice are a Cre-dependent, optogenetic line with a loxP-flanked STOP cassette preventing transcription of a step-function opsin with ultra-high light sensitivity (SOUL; a channelrhodopsin modified to have step function-like properties with extended channel open state and enhanced photocurrent amplitudes) and a tdTomato fluorescent protein. After Cre recombinase exposure, subsequent illumination of SOUL-expressing cells with blue light (~470 nm) leads to stable step in membrane potential (depolarization) in these cells - and the channel can remain in the conducting state for more than 30 minutes, during which time it can be deactivated using orange light (~590 nm).