型号：GM-J#031628 -Available

应用：Vip-IRES-Cre mice have Cre recombinase expression directed to Vip-expressing cells by the endogenous promoter/enhancer elements of the vasoactive intestinal polypeptide locus. Cre activity is detected in the neocortex, hippocampus, olfactory bulb, suprachiasmatic nuclei, and other discrete midbrain and brainstem regions. These mice may be useful to study neural GABAergic circuits throughout the mammalian brain.

型号：GM-J#031612 -Cryorecovery

应用：JamB-Cre knock-in/knock-out targeted mutant mice express cre recombinase from the mouse Jam2 promoter. This strain has been useful in analyzing dendritic morphogenesis of Jam2-expressing retinal ganglion cells (J-RGCs) of the eye.

型号：GM-J#031611 -Cryorecovery

应用：Cdh4CreER knock-in/knock-out mice express tamoxifen-inducible cre/ERT2 from the mouse Cdh4 promoter. In conjunction with a floxed Stop EYFP reporter allele, this strain has been useful in labeling all 4 published Foxp2-expressing retinal ganglion cell types in the eye.

型号：GM-J#031570 -Cryorecovery

应用：Ai170(TIT2L-ASAP2s-Kv-ICL-tTA2)-D (or Ai170D) mice are a Cre/Tet-dependent, voltage-sensitive, fluorescent line for neuronal soma and proximal dendrites - created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). Exposure to Cre recombinase removes both STOP cassettes - resulting in expression of tTA2 and ASAP2s-Kv (highly-sensitive green fluorescent voltage indicator with Kv2.1-tag). ASAP2s-Kv expression may then be diminished by doxycycline. Ai170D mice may be useful for in vivo imaging of voltage dynamics in soma and proximal dendrites.

型号：GM-J#031569 -Cryorecovery

应用：Ai169(TIT2L-ASAP2s-ICL-tTA2)-D (or Ai169D) mice are a Cre/Tet-dependent, voltage-sensitive, fluorescent line - created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). Exposure to Cre recombinase removes both STOP cassettes - resulting in expression of tTA2 and ASAP2s (green fluorescent voltage indicator with high sensitivity). ASAP2s expression may then be diminished by doxycycline. Ai169D mice may be useful for in vivo imaging of voltage dynamics.

型号：GM-J#031565 -Cryorecovery

应用：Bap1lacZ mice express a β-galactosidase gene and are null for Bap1, in addition, exons 6-12 are flanked by loxP sites in this conditional knock-out-first strain. These mice may be useful in studies of clear cell renal carcinoma and von Hippel-Lindau syndrome.

型号：GM-J#031562 -Available

应用：Ai162(TIT2L-GC6s-ICL-tTA2)-D (also called Ai162D) mice are a Cre-dependent, Tet-controllable, fluorescent calcium-indicator tool strain - created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). Exposure to Cre recombinase removes both STOP cassettes, resulting in expression of tTA2 and GCaMP6s (an ultrasensitive detector of single neuronal action potentials with slower decay and response kinetics). GCaMP6s expression may then be diminished by doxycycline.

型号：GM-J#031561 -Cryorecovery

应用：Ai161(TIT2L-GFP-ICR-tTA2)-D (also called Ai161D) mice are a dual-recombinase responsive (Dre and Cre-dependent), Tet-controllable fluorescent reporter line, created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). Exposure to Dre recombinase removes the rox-flanked STOP cassette and results in tTA2 expression. Subsequent exposure to Cre recombinase removes the loxP-flanked STOP cassette - allowing the tTA2 to induce EGFP expression. The EGFP expression may then be diminished by doxycycline. Ai161D mice allow intersectional genetic fate mapping of different cell subpopulations defined by the overlap of the two gene promoters driving the expression of each recombinase.

型号：GM-J#031520 -Cryorecovery

应用：Tbx18-CreERT2 knock-in/knock-out has the endogenous T-box18 promoter/enhancer sequences directing expression of tamoxifen-inducible Cre recombinase. These mice allow specific and inducible genetic manipulations in vivo for studying pericytes and vascular smooth muscle cells in multiple tissues, as well as proepicardium/epicardium cell lineages and pacemaker cells of the sino-atrial node.

型号：GM-J#031519 -Cryorecovery

应用：Tbx18:nlacZ/nGFP knock-in/knock-out has the endogenous T-box18 promoter/enhancer sequences directing expression of nuclear-localized lacZ before exposure to Cre recombinase. Subsequent Cre recombination results in nuclear GFP fluorescence. These mice may be useful in studying pericytes and vascular smooth muscle cells in multiple tissues, as well as proepicardium/epicardium cell lineages, cardiac fibroblasts and pacemaker cells of the sino-atrial node.