型号：GM-J#031487 -Cryorecovery

应用：Agtr1a-2A-Cre knock-in mice are designed to have Cre recombinase expression directed to Agtr1a-expressing cells. Cre activity recapitulates that of the endogenous Agtr1a gene in the brain. These mice may be used to generate conditional mutations for studying neural circuits underlying thirst, vasopressin secretion, and fluid homeostasis.

型号：GM-J#031485 -Cryorecovery

应用：This knock-in/knock-out strain, backcrossed to C57BL/6J from the original mixed genetic background (see Stock No. 030357), expresses cre recombinase from the Pou4f2 promoter. In the original line, cre expression is observed in the retina, brain, intestines, heart, and gonads.

型号：GM-J#031437 -Cryorecovery

应用：Tcf4CreERT2 knock-in/knock-out mice express an inducible Cre/ERT2 fusion protein in connective tissue fibroblasts.

型号：GM-J#031386 -Cryorecovery

应用：Esr1-iCre knock-in/knock-out mice express codon optimized Cre recombinase from the endogenous Esr1 locus. Cre recombinase expression mimics endogenous Esr1 gene expression.

型号：GM-J#031365 -Cryorecovery

应用：IL-9 reporter (9er) knock-in/knock-out mice express humanized cre recombinase (hCre; iCre) and EYFP fluorescent from the mouse Il9 promoter. Endogenous Il9 expression is blocked. This strain is useful in labeling and manipulating cells expressing Il9, for example group 2 innate lymphoid cells (ILC2) cells associated with chitin-induced inflammatory responses in the lung.

型号：GM-J#031364 -Cryorecovery

应用：ChiaRed mice, useful in studies of chitin-induced inflammation and age-related lung fibrosis, express tdTomato and humanized cre recombinase (hCre; iCre) from the mouse Chia1 (AMCase) gene. Endogenous expression of Chia1 is knocked out in this allele.

型号：GM-J#031358 -Cryorecovery

应用：Tg(Tff1-cre/ERT2,Tff2-rtTA,Tff3-luc) transgenic mice express tamoxifen-inducible Cre recombinase, doxycline-mediated rtTA and luciferase in gastric epithelium.

型号：GM-J#031334 -Cryorecovery

应用：Ai134(TITL-ChR2H134R-EYFP)-D mice (also called Ai134D or Ai134(TITL-ChR2-YFP)-D) are a Cre/Tet-dependent, optogenetic line - created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). Following Cre-mediated removal of the STOP cassette, they may be used to generate Tet-Off/Tet-On mutant animals with conditional (inducible/reversible) expression of an improved channelrhodopsin2/EYFP fusion protein (ChR2(H134R)-EYFP). Subsequent illumination of ChR2(H134R)-expressing (EYFP fluorescent) cells with blue light leads to reversible photostimulation of action potential firing/neural activity in these cells.

型号：GM-J#031333 -Cryorecovery

应用：Npr3-IRES2-Cre-D knock-in mice are designed to have Cre recombinase expression/activity directed by the endogenous natriuretic peptide receptor 3 promoter/enhancer sequences. In the brain, Cre expression is observed to be enriched in cortical layer 5 and in restricted cell populations within the hippocampal formation. These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping in NPR3-expressing cells.

型号：GM-J#031332 -Cryorecovery

应用：Vipr2-IRES2-Cre-D knock-in mice are designed to have Cre recombinase expression/activity directed by the endogenous vasoactive intestinal peptide receptor 2 promoter/enhancer sequences. In the brain, it is observed in arcuate hypothalamic nucleus, dorsal lateral geniculate nucleus, ventral nucleus of the thalamus and bed nuclei of the stria terminalis, with scattered expression in superior colliculus and throughout the cortex. These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping in VIPR2-expressing cells.