型号：GM-J#039008 -Available For Pre-Order

应用：Rosa26LSL-DPR dual pathway reporter (DPR) mice conditionally express fluorescent Erk kinase translocation reporter (Erk-KTR/mTagBFP2), a fluorescent histone 2B chromatin/nucleus tag (H2B/iRFP713), and the N-terminal regulatory domain of Nfatc2 fused to the mRuby3 reporter (Nfatc2/mRuby3) from the Gt(ROSA)26Sor locus enabling live-cell in vivo studies of T cell receptor signaling pathway dynamics.

型号：GM-J#039003 -Available For Registering Interest

应用：FLIM-compatible A Kinase Activity Reporter (FL-AK, FLIM-AKARflox) mice express the FLIM-AKAR optical fluorescent reporter in a Cre-dependent manner. Cre recombinase-mediated excision of a loxP-flanked Stop cassette enables the observation of protein kinase A (PKA) activity with cellular resolution in real time. This strain has been useful in revealing PKA activity dynamics in genetically defined cell types via fluorescence lifetime imaging microscopy (FLIM) or photometry in brain slices and in vivo.

型号：GM-J#038999 -Available For Pre-Order

应用：DBA/2J-VGlut2-Cre congenic mice were generated through repeated crosses of Vglut2-ires-cre knock-in (C57BL/6J) (Stock No. 028863) animals to inbred DBA/2J mice (Stock No. 000671). The DBA/2J background of this line has made it particularly useful in studies of glaucoma.

型号：GM-J#038998 -Available For Pre-Order

应用：DBA/2J-OMM-GFP congenic mice were generated through repeated crosses of MitoTag (Rosa26-CAG-LSL-GFP-OMM; Stock No. 032675) animals to inbred DBA/2J mice (Stock No. 000671). The DBA/2J background of this line has made it particularly useful in studies of glaucoma.

型号：GM-J#038988 -Available For Pre-Order

应用：DAT-Cre MCUfl mice, based on a compound mutant strain described in Zampese, 2022 (PMID:36179023), were generated through an intercross of mice carrying an allele of the mouse Mcu (mitochondrial calcium uniporter) gene in which exons 5 and 6 are flanked by loxP sites (Stock No. 029817) with DATIREScre animals that direct Cre recombinase expression to dopaminergic neurons without disrupting endogenous dopamine transporter expression (Slc6a3tm1.1(cre)Bkmn; Stock No. 006660). Cre-mediated excision of the floxed region results in a knock-out of Mcu in dopaminergic neurons, useful in studies of Parkinson's disease (PD).

型号：GM-J#038959 -Available For Pre-Order

应用：Slc17a8-IRES2-Cre-neo knock-in mice have Cre recombinase expression directed to Vglut3-expressing cells, without disrupting endogenous vesicular glutamate transporter 3 expression. These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping related to glutamatergic synaptic vesicle trafficking.

型号：GM-J#038958 -Available For Pre-Order

应用：Rorb-IRES2-Cre-neo knock-in mice have Cre recombinase expression directed to Rorb-expressing cells, without disrupting endogenous RAR-related orphan receptor beta expression. These mice may be useful for studying this nuclear hormone receptor/DNA-binding protein in hormone-responsive gene expression and behavior.

型号：GM-J#038957 -Cryorecovery

应用：Cartpt-IRES2-Cre-neo knock-in mice have Cre recombinase expression directed to CART prepropeptide-expressing cells, without disrupting endogenous Cartpt expression. These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping in subgroups of brain tissues (including cortex, cerebral nuclei, hypothalamus and midbrain) in regards to feeding, appetite and stress response, as well as gene regulation by cocaine and other drugs.

型号：GM-J#038956 -Cryorecovery

应用：Npr3-IRES2-CreERT2-neo knock-in mice are designed to have cre/ERT2 expression/activity directed by the endogenous natriuretic peptide receptor 3 promoter/enhancer sequences. In the brain, cre/ERT2 expression is observed to be enriched in cortical layer 5 and in restricted cell populations within the hippocampal formation. These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping in NPR3-expressing cells.

型号：GM-J#038955 -Cryorecovery

应用：Npr3-IRES2-Cre-neo knock-in mice are designed to have Cre recombinase expression/activity directed by the endogenous natriuretic peptide receptor 3 promoter/enhancer sequences. In the brain, Cre expression is observed to be enriched in cortical layer 5 and in restricted cell populations within the hippocampal formation. These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping in NPR3-expressing cells.