型号：GM-J#039168 -Available For Pre-Order

应用：Humanized E46K SNCA-GR (gene replacement) mice are a knock-in/knock-out model in which the mouse genomic region from Snca (synuclein, alpha) is exchanged for 158 kb of the human SNCA genomic region including the E46K mutation. E46K is associated with Parkinson's disease (PD). This strain may be used to explore more fully the role of SNCA in Parkinson's disease (PDD), dementia with Lewy bodies (DLB), multiple system atrophy (MSA), and Alzheimer's disease.

型号：GM-J#039167 -Available For Pre-Order

应用：Humanized A53T SNCA-GR (gene replacement) mice are a knock-in/knock-out model in which the mouse genomic region from Snca (synuclein, alpha) is exchanged for 158 kb of the human SNCA genomic region including the A53T mutation. A53T is associated with early-onset Parkinson's disease (PD). This strain may be used to explore more fully the role of SNCA in Parkinson's disease (PDD), dementia with Lewy bodies (DLB), multiple system atrophy (MSA), and Alzheimer's disease.

型号：GM-J#039166 -Available For Pre-Order

应用：Humanized wildtype SNCA-GR (gene replacement) mice are a knock-in/knock-out model in which the mouse genomic region from Snca (synuclein, alpha) is exchanged for 158 kb of the human SNCA genomic region. These mice may serve as base models into which additional alterations can be introduced to explore more fully the role of SNCA in Parkinson's disease (PDD), dementia with Lewy bodies (DLB), multiple system atrophy (MSA), and Alzheimer's disease.

型号：GM-J#039156 -Available For Pre-Order

应用：Zic5-CreER knock-in/knock-out mice express a CreER fusion protein driven by the zinc finger protein of the cerebellum 5 (Zic5) endogenous promoter while abolishing endogenous Zic5 expression. When bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible Cre-mediated recombination will result in the deletion of the floxed sequences in the Zic5-expressing cells of the offspring. These mice may be useful when studying the fate of pre-migratory neural crest cells.

型号：GM-J#039125 -Available For Pre-Order

应用：Gpr17-Cre mice constitutively express Cre recombinase from the mouse G protein-coupled receptor 17 (Gpr17) promoter in CNS cells of the oligodendrocyte lineage and a subset of astrocytes when recombination is induced embryonically. Expression of the targeted Gpr17 gene is not affected by the knock-in.

型号：GM-J#039034 -Available For Registering Interest

应用：This quadruple Htra knock-out has deletions in Htra1 exons 2-3, Htra2 exons 2-4, Htra3 exon 3, and Htra4 exons 4-6. This strain may be useful in studies of age-related diseases including Parkinson's disease and age-related macular degeneration.

型号：GM-J#039032 -Available For Registering Interest

应用：Htra2flox mice possess loxP sites flanking exons 2-4 of the Htra2 (HtrA serine peptidase 2) gene. These floxed mice are useful for tissue specific deletion of Htra2 in studies of neurodegeneration, mitochondrial integrity, and Parkinson's disease.

型号：GM-J#039022 -Available For Pre-Order

应用：Tacr1CreERT2 knock-in/knock-out mice express tamoxifen-inducible Cre recombinase from the mouse tachykinin receptor 1 (Tacr1) promoter in Tacr1-expressing cells of the spinal cord and brain, including spinal projection neurons of the anterolateral pathway. This strain may be useful in studies of nociception (pain and affective touch).

型号：GM-J#039021 -Cryorecovery

应用：Gpr83CreERT2 knock-in/knock-out mice express tamoxifen-inducible Cre recombinase from the mouse G protein-coupled receptor 83 (Gpr83) promoter in Gpr83-expressing cells of the spinal cord and brain, including spinal projection neurons of the anterolateral pathway. This strain may be useful in studies of nociception (pain and affective touch).

型号：GM-J#039016 -Available For Pre-Order

应用：NOD.B10Cre-Vav transgenic mice have the mouse HS21/45 control regions directing expression of an optimized variant of Cre recombinase (iCre) to hematopoietic cells (and their progenitors), on a NOD.B10 genetic background (Stock No. 002591). This congenic strain has the MHC H2b haplotype from the C57BL/10SnJ strain with mice exhibiting some but not all of the immune dysfunctions of NOD/LtJ (Stock No. 001976) mice. These mice may be useful for generating conditional mutations in hematopoietic cells.