型号：GM-J#038773 -Available For Pre-Order

应用：SNCA*E57K(16) transgenic mice express human α-synuclein that contains an E57K amino acid substitution driven by the mouse thymus cell antigen 1, theta (Thy1) promoter. These mice may be useful in studying human neuronal α-synucleinopathies, such as familial Parkinson's disease.

型号：GM-J#038728 -Available For Pre-Order

应用：Ank2fl mice possess an frt-flanked cassette with an IRES-EGFP-polyA, a loxP site, and a neo cassette upstream of exon 4 of the Ankyrin 2, brain (Ank2) gene. Exon 4 is floxed, resulting in a total of 3 loxP sites. This strain may be useful for studying linker function between cytoskeleton and transmembrane protein in neurons associated with cardiac dysfunctions and the onset of Autism spectrum disorders (ASD) and seizures.

型号：GM-J#038709 -Available For Pre-Order

应用：B6.Spp1fl-EGFP-stop-tdTomato mutant mice possess loxP sites flanking sequence encoding exons 4-7 of the secreted phosphoprotein 1 gene and an EGFP sequence with a stop cassette. They also contain a tdTomato with a stop cassette downstream of the 3' loxP site. This strain may be useful for generating conditional mutants in applications related to bone growth/metabolism, cancer, and neurobiology.

型号：GM-J#038650 -Available For Pre-Order

应用：Crfr1-cre transgenic mice express icre and tdTomato under the control of the mouse Crhr1 promoter in neurons in the hypothalamic paraventricular nucleus (PVN). They may be useful for visualizing and studying growth and differentiation of CRFR1+ cells and neurons and their role of this microcircuit in regulating hypothalamic-pituitary-adrenal axis activity during stress responses.

型号：GM-J#038640 -Available For Pre-Order

应用：CRISPR/Cas9 generated Rtkn2CreER knock-in/knock-out mice have cre-ERT2 replacing the start codon of the endogenous rhotekin 2 gene. They are useful for applications requiring tamoxifen-induced deletion of floxed sequences in lung alveolar type 1 cells.

型号：GM-J#038639 -Available For Pre-Order

应用：ROSAKaleidoscope mice carry three fluorescent cell biology reporters separated by 2A self-cleaving sequences downstream of a floxed STOP cassette inserted into the ubiquitous Gt(ROSA)26Sor gene. These mice are a tricolor tunable reporter mouse line useful for simultaneous imaging of lysosomes, mitochondria, and microtubules in the native tissues at a single-cell resolution.

型号：GM-J#038602 -Available For Pre-Order

应用：CRISPR/Cas9 generated Car4CreER knock-in/knock-out mice have cre-ERT2 replacing the start codon of the endogenous carbonic anhydrase 4 gene. They are useful for applications requiring tamoxifen-induced deletion of floxed sequences in Cap2 pulmonary endothelial cells called aerocytes.

型号：GM-J#038595 -Cryorecovery

应用：X-linked DCX-Cre/ER mice express a tamoxifen-inducible Cre recombinase from the mouse Dcx (doublecortin) gene in adult-born neurons of the subventricular zone and hippocampal subgranular zone.

型号：GM-J#038587 -Cryorecovery

应用：Foxi3CreER knock-in/knock-out mice have a CreER fusion protein driven by the Foxi3 endogenous promoter, while abolishing endogenous Foxi3 expression. This strain may be useful for Cre-lox studies of Foxi3-expressing cells during embryogenesis; specifically, neuroepithelial cells, pharyngeal arches and pouches, as well as hair and tooth progenitor cells. Although eGFP is also present in this Foxi3CreER allele, its low level of expression from the construct did not allow detection of the eGFP protein, either by native fluorescence or by immunostaining with GFP antibodies.

型号：GM-J#038582 -Cryorecovery

应用：Fbxo2CreERT2 knock-in/knock-out mice express a CreER fusion protein driven by the F-box protein 2 (Fbxo2) endogenous promoter, while abolishing endogenous Fbxo2 expression. When these mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated