型号：GM-J#069595-JAX -Available

应用：LratCre transgenic mice express a cre recombinase directed by mouse Lrat (lecithin-retinol acyltransferase [phosphatidylcholine-retinol-O-acyltransferase]) promoter elements. Cre recombinase activity is observed in hepatic stellate cells in the liver as well as in Lrat-expressing cells of other organs. This strain may be useful for in vivo lineage tracing and functional analysis of hepatic stellate cells in liver fibrosis.

型号：GM-J#069559-JAX -Available For Registering Interest

应用：Hb9::CreERT2 transgenic mice express a tamoxifen inducible Cre recombinase/ERT2 fusion under the control of the mouse Mnx1 (also known as Hb9) promoter elements. Cre recombinase activity is observed specifically in Hb9-expressing interneurons. This strain may be useful in studies of neural circuits.

型号：GM-J#069553-JAX -Cryorecovery

应用：These Foxp3ΔEGFPiCre knock-in/knock-out mice have an IRES-EGFP/icre recombinase fusion gene inserted in the X-linked forkhead box P3 (Foxp3) gene. Male hemizgyotes are runted and die of autoimmune lymphoproliferation. This strain may useful tool for studying Treg function and development.

型号：GM-J#068344-JAX -Cryorecovery

应用：Adgra3cre knock-in/knock-out mice carry a human diphtheria toxin receptor gene (HBEGF) and an inducible Cre recombinase/ERT2 fusion under the control of the Adgra3 (adhesion G protein-coupled receptor A3 or Gpr125) promoter. Embryonic Adgra3 (Gpr125) is expressed in multiple stem cell/progenitor compartments and high expression of Gpr125 is correlated with tumor onset and outcome in several types of cancers. Homozygous mice develop blepharitis, which progresses to blepharedema as well as several characteristics of dry eye syndrome. This strain may be useful in studies of dry eye syndrome as well as in identifying stem/progenitor cells involved in cancers.

型号：GM-J#068163-JAX -Cryorecovery

应用：Foxl1CreERT2-2A-tdTomato knock-in/knock-out mice have an inducible Cre recombinase/ERT2 fusion followed by a tdTomato reporter inserted into the endogenous translation start site of the forkhead box L1 (Foxl1) gene. These mice can be to identify cells in the gastrointestinal tract.

型号：GM-J#068122-JAX -Cryorecovery

应用：Tg(Tshb-cre) transgenic mice express a cre recombinase directed by mouse Tshb (thyroid stimulating hormone, beta subunit) promoter elements. Cre recombinase activity is observed in pituitary thyrotroph cells. This strain may be useful for in vivo lineage tracing and functional analysis of thyrotrophs.

型号：GM-J#068075-JAX -Cryorecovery

应用：Nanog-creER transgenic mice express a tamoxifen-inducible (Esr1*) Cre recombinase directed by mouse Nanog (Nanog homeobox) promoter elements. When induced, Cre recombinase activity is observed in embryonic stem cells. This strain may be useful for in vivo lineage tracing.

型号：GM-J#068059-JAX -Cryorecovery

应用：Pou3f4 knock-in/knock-out mice contain a Cre recombinase that replaces the Pou3f4 (POU domain, class 3, transcription factor 4) coding region. Females homozygous for the mutation and males hemizygous for the X-linked mutation are deaf due to reduced endocochlear potential; mutants also show a failure of auditory spiral ganglion neuron radial bundle fasciculation and synapse formation in the cochlea.

型号：GM-J#067446-JAX -Cryorecovery

应用：Ambn-IRESCre knock-in mice are designed to have the endogenous Ambn promoter/enhancer regions directing expression of cre recombinase to the tooth, with minimal disruption to endogenous Ambn (ameloblastin) expression. These mice are useful for studying dental enamel development.

型号：GM-J#067402-JAX -Cryorecovery

应用：Odam-IRESCre knock-in mice are designed to have the endogenous Odam promoter/enhancer regions directing expression of cre recombinase to the tooth, with minimal disruption to endogenous Odam expression. These mice are useful for studying tooth enamel and periodontitis.