型号：GM-J#006582 -Available

应用：Parkin knock-out mice (homozygous) have increased extracellular dopamine concentration in the striatum, dysfunctional nigrostriatal pathways, and dysfunctional mitochondria. These mice model the exon 3 deletion mutation most common in human autosomal recessive juvenile parkinsonism (AR-JP; Parkinson disease 2; PARK2) patients and may be useful in studies of Parkinson's disease, dopamine regulation, nigrostriatal function, mitochondrial function, and other neurobiological research.

型号：GM-J#006577 -Cryorecovery

应用：Homozygous knock-out mice of this strain exhibit hypokinesia and nigrostriatal dopaminergic deficits. These mutant mice may be useful in studies of Parkinson's disease, dopaminergic physiology, nigrostriatal function, locomotor inactivity, and other neurobiological research.

型号：GM-J#006477 -Not Available At Jax

应用：These ZW mice harbor a Cre-conditional pCZW transgene and have widespread expression of lacZ under the control of the CMV enhancer/chicken actin promoter. When bred to mice expressing Cre recombinase, the "floxed" lacZ sequence is removed in the resulting offspring, and lacZ expression is replaced by wheat germ agglutinin (plant lectin) expression in all cre-expressing cells. These ZW mice may be useful for global expression of lacZ or, when crossed to a cre-expressing strain, for tracing transneuronal or trans-synaptic connections and circuits in brain regions or in the spinal cord.

型号：GM-J#006475 -Cryorecovery

应用：MCK-Cre transgenic mice have the Cre recombinase gene driven by the muscle creatine kinase promoter, andCre activity is observed in skeletal and cardiac muscle. When bred with mice containing a loxP-flanked sequence of interest, Cre-mediated recombination will result in skeletal and cardiac muscle deletion of the flanked genome.

型号：GM-J#006474 -Available

应用：Cre recombinase expression in these transgenic mice is driven by the endogenous promoter/enhancer elements of the glutamate receptor, ionotropic, kainate 4 (Grik4) gene, and is observed primarily in the CA3 region of the hippocampus. These cre-expressing mice may be useful in neurological studies involving hippocampal function, learning and memory, and pyramidal cell function and physiology.

型号：GM-J#006465 -Cryorecovery

应用：These ZW mice harbor a Cre-conditional pCZW transgene and have widespread expression of lacZ under the control of the CMV enhancer/chicken actin promoter. When bred to mice expressing Cre recombinase, the "floxed" lacZ sequence is removed in the resulting offspring, and lacZ expression is replaced by wheat germ agglutinin (plant lectin) expression in all cre-expressing cells. These ZW mice may be useful for global expression of lacZ or, when crossed to a cre-expressing strain, for tracing transneuronal or trans-synaptic connections and circuits in brain regions or in the spinal cord.

型号：GM-J#006451 -Cryorecovery

应用：When these Sim1-Cre mice are bred with mice containing a loxP-flanked sequence of interest, Cre-mediated recombination will result in deletion of the flanked sequences in Sim1-expressing tissues (including hypothalamus). As such, Sim1-Cre transgenic mice may be useful in studying body weight homeostasis, obesity, leptin metabolism, or as a reporter strain for Sim1-transcription factor activity.

型号：GM-J#006410 -Available Now

应用：ChAT-IRES-Cre knock-in mice express Cre recombinase in cholinergic neurons, without disrupting endogenous Chat expression. These mice may be useful in neurobiological research of motor function, learning and memory, Alzheimer's disease, and Down syndrome, as well as obesity and diabetes research.

型号：GM-J#006405 -Cryorecovery

应用：Cre activity under control of the muscle creatine kinase (Ckm) promoter is expressed in skeletal and cardiac muscle.

型号：GM-J#006395 -Cryorecovery

应用：When these Sim1-Cre mice are bred with mice containing a loxP-flanked sequence of interest, Cre-mediated recombination will result in deletion of the flanked sequences in Sim1-expressing tissues (including hypothalamus). As such, Sim1-Cre transgenic mice may be useful in studying body weight homeostasis, obesity, leptin metabolism, or as a reporter strain for Sim1-transcription factor activity.