型号：GM-J#007251 -Available

应用：Hippocampal neurons (primary culture) from embryos that are homozygous for the microtubule-associated protein tau (Mapt) knock-out mutation, TAU-/-, have delayed axonal extension and shorter total dendritic length and abnormal mitochondrial placement and movement. This mutant mouse strain may be useful in studies of neuronal development, axonogenesis, and organelle movement.

型号：GM-J#007179 -Cryorecovery

应用：When these UBC-Cre-ERT2 mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in widespread cells/tissues.

型号：GM-J#007004 -Available

应用：When these Camk2a-tTA transgenic mice are mated to strain carrying a gene of interest under the regulatory control of a tetracycline-responsive promoter element (TRE; tetO), expression of the target gene can be blocked by administration of the tetracycline analog, doxycycline. These mice are a "Tet-Off" tool that allow the inducible expression of genes in forebrain neurons, and may be useful in studying brain disorders such as Alzheimer's, Parkinson's disease, or other neurodegenerative diseases.

型号：GM-J#007001 -Available

应用：When these UBC-Cre-ERT2 mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in widespread cells/tissues.

型号：GM-J#006954 -Cryorecovery

应用：Ddx4-Cre (Vasa-Cre) transgenic mice have Cre recombinase expression directed to male and female embryonic germ cells. These mice may be useful in generating conditional germ cell knock-outs in both males and females for studies including infertility, gonadogenesis, gametogenesis, and the assembly, activation, and growth of primordial follicles.

型号：GM-J#006953 -Cryorecovery

应用：N1::cre mutant mice express a Notch1-Cre fusion protein formed by the insertion of Cre recombinase into the Notch1 locus, replacing the intracellular domain (NICD1).Interaction of N1::cre fusion receptors in vivo with Notch-DSL ligands results in proteolytic cleavage of the transmembrane domain tether and subsequent release of Cre recombinase protein from the plasma membrane. When bred to mice with a loxP-flanked reporter sequence, cell descendants have differential Cre-mediated reporter protein labeling; Notch1 signaling in actively cycling stem/progenitor cells will mark all their descendants producing a "clone", whereas Notch1 activation in transit amplifying or differentiating cells will result in small clones (2-4 cells) or in salt-and-pepper patterns of individually labeled cells. These N1::cre mice make it possible to follow the deccendents of cells that have undergone Notch1 activation, throughout development, self-renewal and malignancy.

型号：GM-J#006889 -Cryorecovery

应用：Cre recombinase activity in homozygous mice for this transgene is restricted to thymocytes.

型号：GM-J#006888 -Cryorecovery

应用：Cre recombinase expression in these mice is controlled by the zona pellucida 3 (Zp3) gene and is expressed in oocytes.

型号：GM-J#006881 -Cryorecovery

应用：These mice express Cre recombinase directed by endogenous Aqp2 promoter/enhancer elements. When bred to mice with a floxed gene of interest, Cre recombinase activity is observed in the collecting duct of kidney cells and in sperm of the testes. These mice may be used to generate conditional mutations for studying nephrology, physiology, metabolism, or type II diabetes.

型号：GM-J#006878 -Cryorecovery

应用：Mice homozygous for the transgelin knock-in allele (Taglntm2(cre)Yec or commonly referred to as SM22alpha-CreKI) exhibit Cre recombinase activity in adult smooth muscle cells and cardiac myocytes. These mice may be useful for Cre-lox technology applications in studying smooth muscle and cardiac gene function, as well as cardiovascular disease.