型号：GM-J#029124 -Cryorecovery

应用：These mice carry the Gba1tm1.1Mjff allele (Stock No. 019106) and the Tg(Thy1-SNCA)15Mjff transgene (Stock No. 017682). They have applications related to Parkinson's disease, Gaucher disease and synucleinopathies, and neurodegeneration elicited by the aggregation of SNCA. While increased SCNA pathology and grip strength reductions are observed in this model, the nigrostriatal system remains largely intact. Neuroinflammation is not exacerbated by the GBA D409V mutation.

型号：GM-J#029100 -Available

应用：Fxnnull::MCK-Cre mice harbor a frataxin global knock-out allele and a cardiac/skeletal muscle-specific Cre recombinase transgene. When heterozygous for Fxnnull and hemizygous or homozygous for MCK-Cre, these double mutant mice are "phenotypically normal" and are a parental control used to generate the progressive cardiomyopathy mouse line Fxnflox/null::MCK-Cre (Stock No. 029720) - which is useful in studying Friedreich's Ataxia.

型号：GM-J#029043 -Cryorecovery

应用：Ai38 mice express the fluorescent calcium indicator protein GCaMP3 after exposure to Cre recombinase. Following subsequent calcium binding (such as neuronal activation), bright EGFP fluorescence is observed.

型号：GM-J#029040 -Cryorecovery

应用：The RC::FPDi dual-recombinase responsive allele has a frt-flanked STOP and loxP-flanked mCherry::STOP all preventing transcription of an HA-tagged hM4Di - a mutant G protein-coupled DREADD receptor that induces the canonical Gi/o pathway specifically following administration of its pharmacologically inert ligand (CNO). FLP recombinase results in mCherry fluorescence, and further exposure to Cre recombinase results in hM4Di expression in the overlapping populations. The RC::FPDi allele and its derivatives allow conditional intersectional genetics for chemogenetic studies to express an inhibitory DREADD that effectively induces membrane hyperpolarization and neuronal silencing.

型号：GM-J#028941 -Cryorecovery

应用：These Nrl-Cre mice recapitulate developmental expression patterns of the endogenous mouse Nrl gene without any overt impact on retinal structure or function. They enable rod precursor cell-specific excision of floxed genomic segments in retinal models of neurogenesis and differentiation.

型号：GM-J#028867 -Available

应用：Gad2-IRES-Cre knock-in mice have Cre recombinase expression directed to GAD2 positive neurons. These mice may be used to generate conditional mutations for studying GAD2 cell populations.

型号：GM-J#028866 -Available

应用：Ai96(RCL-GCaMP6s) (also called Ai96) mice are a Cre-dependent, fluorescent, calcium-indicator tool strain. Ai96 has a floxed-STOP cassette preventing transcription of the GCaMP6 slow variant calcium indicator (GCaMP6s; an ultrasensitive detector of single neuronal action potentials with slower decay and response kinetics). After Cre exposure, increased EGFP fluorescence is observed following calcium binding (such as neuronal activation).

型号：GM-J#028865 -Available

应用：Ai95(RCL-GCaMP6f)-D (also called Ai95D) mice are a Cre-dependent, fluorescent, calcium-indicator tool strain. Ai95D has a floxed-STOP cassette preventing transcription of the GCaMP6 fast variant calcium indicator (GCaMP6f; a detector of single neuronal action potentials with fast response kinetics). After Cre exposure, bright EGFP fluorescence is observed following calcium binding (such as neuronal activation).

型号：GM-J#028864 -Cryorecovery

应用：Sst-IRES-Cre knock-in mice express Cre recombinase in somatostatin-expressing neurons. These mice may be useful in studying dendritic inhibitory interneurons such as Martinotti cells and Oriens-Lacunosum-Moleculare cells.

型号：GM-J#028863 -Available Now

应用：Vglut2-ires-Cre knock-in mice have Cre recombinase expression directed to excitatory glutamatergic neuron cell bodies, without disrupting endogenous vesicular glutamate transporter 2 expression. These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping related to glutamatergic neurons.