产品型号：GM-J#029040 -Cryorecovery

产品应用：The RC::FPDi dual-recombinase responsive allele has a frt-flanked STOP and loxP-flanked mCherry::STOP all preventing transcription of an HA-tagged hM4Di - a mutant G protein-coupled DREADD receptor that induces the canonical Gi/o pathway specifically following administration of its pharmacologically inert ligand (CNO). FLP recombinase results in mCherry fluorescence, and further exposure to Cre recombinase results in hM4Di expression in the overlapping populations. The RC::FPDi allele and its derivatives allow conditional intersectional genetics for chemogenetic studies to express an inhibitory DREADD that effectively induces membrane hyperpolarization and neuronal silencing.