型号：GM-J#030206 -Cryorecovery

应用：The RC::FPSit dual-recombinase intersectional allele has a frt-flanked STOP and loxP-flanked STOP that prevent transcription of synaptophysin-EGFP fusion protein and tdTomato. Exposure to FLP and Cre recombinase results in strong EGFP expression enriched at the synapse/synaptic vesicle (axonal boutons [terminal and en passant]) of the neuron subtype(s) defined by the overlap of FLP/Cre expression.

型号：GM-J#030201 -Available

应用：PDGFRβ-P2A-CreERT2 mice express tamoxifen-inducible Cre recombinase under the direction of the murine platelet derived growth factor receptor, beta polypeptide (Pdgfrb) promoter. They are useful for applications requiring tamoxifen-induced deletion of floxed sequences in vascular pericytes.

型号：GM-J#030197 -Cryorecovery

应用：Pdyn-T2A-CreERT2-D knock-in mice express tamoxifen-inducible Cre recombinase from the endogenous prodynorphin promoter/enhancer elements. When induced, CreERT2 expression/activity is observed mainly in central amygdalar nucleus, paraventricular hypothalamic nucleus, nucleus accumbens, caudoputamen and cortex. These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping related to this precursor of opioid peptides.

型号：GM-J#030189 -Cryorecovery

应用：BDNF-2A-Cre knock-in mice are designed to have Cre recombinase expression directed to brain derived neurotrophic factor-expressing cells. Cre activity recapitulates that of the endogenous Bdnf gene in the brain. These mice may be used to generate conditional mutations for studying this neuropeptide/neurotrophin in aspects of neuronal function, including growth/differentiation of neurons and synapses, neurogenesis, synaptic transmission, learning, long-term memory, heat responses and human disease.

型号：GM-J#030182 -Cryorecovery

应用：The Foxc2CreERT2 knock-in/knock-out allele was designed to both abolish endogenous gene function and allow the Foxc2 promoter/enhancer regions to direct tamoxifen-inducible Cre recombinase expression to lymphovenous valves, mural cells and bones of the developing embryo. These mice may be useful for tamoxifen-inducible recombination of lox-flanked (floxed) alleles in developmental studies (including kidney, lymphatic vessels, lymphovenous valves and heart).

型号：GM-J#030170 -Cryorecovery

应用：Rosa26-lsl-mGCaMP3 mice express the membrane-associated fluorescent calcium indicator protein GCaMP3 after exposure to Cre recombinase. Following subsequent calcium binding (such as neuronal activation), bright EGFP fluorescence is observed.

型号：GM-J#030160 -Cryorecovery

应用：Htr1a-IRES2-Cre-D knock-in mice are designed to have Cre recombinase expression/activity directed by the endogenous Htr1a promoter/enhancer sequences. In the brain, it is observed mainly in cortex, hippocampus and retro-hippocamal regions, as well as scattered neurons elsewhere in the brain. These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping in 5-HT1A-expressing cells, as well as serotonin receptor signaling and neurotransmission.

型号：GM-J#030159 -Cryorecovery

应用：Gnb4-IRES2-CreERT2-D knock-in mice express tamoxifen-inducible Cre recombinase from the endogenous guanine nucleotide binding protein (G protein) beta 4 promoter/enhancer elements. When induced, CreERT2 expression/activity is enriched in restricted populations within cortical subplate (claustrum and endopiriform nucleus) and layers 5/6 of lateral areas of cortex. Expression is also observed in some vascular cells. These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping related to this G protein.

型号：GM-J#030158 -Cryorecovery

应用：Esr2-IRES2-Cre-D knock-in mice are designed to have Cre recombinase expression/activity directed by the endogenous Esr2 promoter/enhancer sequences. In the brain, it is observed mainly in medial amygdalar nucleus, bed nuclei of the stria terminalis, paraventricular hypothalamic nucleus, cortical layer 6 and scattered neurons elsewhere in the brain. These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping in ESR2-expressing cells.

型号：GM-J#030155 -Cryorecovery

应用：Adcyap1-2A-Cre knock-in mice are designed to have Cre recombinase expression directed to adenylate cyclase activating polypeptide 1-expressing cells. Cre expression and activity in adult mice recapitulates that of the endogenous Adcyap1 gene in the brain. These mice may be used to generate conditional mutations for studying this neuropeptide/neurotrophin in aspects of neuronal function, including neurotransmission, neuromodulation and neuroendocrine stress responses and heat responses.