型号：GM-J#030290 -Cryorecovery

应用：These knock-in/knock-out targeted mutant mice express tamoxifen-inducible cre-ERT2 fusion protein from the mouse Rorb promoter in the spinal cord dorsal horn and barrel cortex.

型号：GM-J#030289 -Cryorecovery

应用：These knock-in/knock-out targeted mutant mice express tamoxifen-inducible cre-ERT2 fusion protein from the mouse Prkcg promoter in the spinal cord dorsal horn, hippocampus, cerebellum, and corticospinal tract.

型号：GM-J#030277 -Cryorecovery

应用：LSL-Mist1myc transgenic mice express myc-tagged Bhlha15 after exposure to Cre recombinase. Mice are useful when studying pancreatic acinar cell damage and repair during acute pancreatitis.

型号：GM-J#030220 -Cryorecovery

应用：Ai140(TIT2L-GFP-ICL-tTA2)-D (also called Ai140D) mice are a Cre-dependent, Tet-controllable fluorescent reporter line, created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). Exposure to Cre recombinase removes both STOP cassettes - resulting in EGFP fluorescence and tTA2 expression - and that EGFP expression may be diminished/eliminated by doxycycline.

型号：GM-J#030219 -Cryorecovery

应用：Ai139(TIT2L-GFP-ICL-TPT)-D (also called Ai139D) mice are a Cre-dependent, Tet-controllable dual fluorescent reporter line, created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). Exposure to Cre recombinase removes both STOP cassettes - resulting in EGFP fluorescence, tdTomato fluorescence and tTA2 expression - and that EGFP expression may be diminished/eliminated by doxycycline.

型号：GM-J#030218 -Available

应用：Fxnnull::PV-Cre mice harbor a frataxin global knockout allele and a Pvalb knock-in allele directing Cre recombinase expression to parvalbumin-expressing neurons. These mice are a parental control used to generate the progressive ataxia mouse line Fxnflox/null::PV-Cre (Stock No. 029721), and may be useful in studying Friedreich's Ataxia.

型号：GM-J#030217 -Cryorecovery

应用：TITL-R-CaMP1.07-D (Ai143D) mice are a Cre/Tet-dependent, fluorescent calcium-indicator tool strain, created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). Following Cre-mediated removal of the STOP cassette, they may be used to generate Tet-Off/Tet-On mutant animals with conditional (inducible/reversible) expression of R-CaMP1.07 (a red fluorescent calcium-sensing molecule that functions at cellular calcium levels).

型号：GM-J#030216 -Cryorecovery

应用：Ai136(TITL-ReaChR-YFP)-D (also called Ai136D) mice are a Cre/Tet-dependent, optogenetic line, created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). Following Cre-mediated removal of the STOP cassette, they may be used to generate Tet-Off/Tet-On mutant animals with conditional (inducible/reversible) expression of the channelrhodopsin/EYFP fusion protein (ReaChR/EYFP). Subsequent illumination of ReaChR-expressing (EYFP fluorescent) cells with orange-to-red light leads to reversible photostimulation of action potential firing/neural activity in these cells.

型号：GM-J#030215 -Available

应用：The Amigo2-Cre BAC transgene has the adhesion molecule with Ig like domain 2 promoter/enhancer regions directing Cre recombinase expression predominantly to CA2 pyramidal neurons in adult mice. These mice may be useful for recombination of lox-flanked (floxed) alleles in studying neuronal function (sociocognitive memory formation and mental retardation) PDK1-AKT pathway regulation (angiogenesis and anti-apoptosis), T-cell modulation and multiple sclerosis.

型号：GM-J#030213 -Cryorecovery

应用：Ai133(TITL-ssAPEX2tm)-D (also called Ai133D) mice are a Cre/Tet-dependent, substrate-dependent reporter line - created by targeted insertion of floxed-STOP-APEX2 at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). After removal of the floxed-STOP cassette by Cre recombinase, they may be used to generate Tet-Off/Tet-On mutant animals with conditional (inducible/reversible) expression of APEX2 - an engineered peroxidase with improved catalytic efficiency that functions as an electron microscopy tag and a promiscuous labeling enzyme for live-cell proteomics.