型号：GM-J#029789 -Cryorecovery

应用：The H2B-TRAP allele (Translating Ribosome Affinity Purification) has a loxP-flanked STOP preventing transcription of two individual components: H2B/mCherry and EGFP/L10a. When expressed, the H2B/mCherry protein allows nuclei-labeling with mCherry (which enables nuclear isolation by fluorescence-based purification). Furthermore, EGFP/L10a fluorescently tags the translating mRNA polysome complex (which enables isolation of RNAs that are actively engaged by ribosomes). Overall, H2B-TRAP mice are a Cre-inducible tool strain that allows labeling and simultaneous isolation of cell type-specific nuclei and mRNA, and are well-suited for studying epigenomics and transcriptomics from specific cell types within a heterogeneous tissue. Of note, the donating investigator also has available their similar mouse line NuTRAP (Stock No. 029899).

型号：GM-J#029788 -Cryorecovery

应用：These Tyr::CreA transgenic mice have the mouse tyrosinase (Tyr) gene promoter and enhancer driving Cre recombinase expression in melanoblasts and melanocytes. These mice may be useful for Cre-lox studies of the melanocyte lineage, melanocyte development and melanoma cells. The transgene integrated on the X chromosome.

型号：GM-J#029735 -Cryorecovery

应用：The Tg-4EBP1mt transgene has a floxed-GFP-3xSTOP cassette preventing expression of constitutively active, mTORC1-nonresponsive mutant variant of human EIF4EBP1. These mice may be useful for Cre recombinase-inducible studies involving mTOR complex 1 signaling and metabolism.

型号：GM-J#029721 -Available

应用：Fxnflox/null::PV-Cre mice have a Cre-conditional frataxin allele, global knockout frataxin allele and parvalbumin neuron-specific Cre recombinase knockin allele - useful to study Friedreich's Ataxia.

型号：GM-J#029720 -Available

应用：Fxnflox/null::MCK-Cre mice have a Cre-conditional frataxin allele, a global knockout frataxin allele and a cardiac/skeletal muscle-specific Cre recombinase transgene - and are useful in studying Friedreich's Ataxia.

型号：GM-J#029690 -Cryorecovery

应用：Foxg1-IRES-Cre knock-in mice contain a Cre recombinase sequence downstream of the Foxg1 promoter. These mice express FOXG1 in the telencephalon.

型号：GM-J#029684 -Available

应用：Pdgfr-β-CreERT2 transgenic mice express tamoxifen-inducible Cre recombinase under the direction of the murine platelet derived growth factor receptor, beta polypeptide (Pdgfrb) promoter/enhancer regions. They are useful for applications requiring tamoxifen-induced deletion of floxed sequences in vascular pericytes.

型号：GM-J#029679 -Cryorecovery

应用：Ai155 Optopatch3 mice, an improved version of Optopatch2, are a sensitive, fast optogenetic tool for targeted, simultaneous optical perturbation and optical measurement of membrane voltage. Conditional expression is dependent on cre-mediated excision of a floxed Stop cassette.

型号：GM-J#029677 -Cryorecovery

应用：Conditional expression of Optopatch2 (an optogenetic actuator/indicator) is under the control of a tetracycline response element (TRE; tetO) and floxed Stop integrated in the Igs7 (TIGRE) locus. Functionality of Optopatch2 requires the expression of tTA as well as cre recombinase-mediated excision of the floxed Stop. This is line Ai141.

型号：GM-J#029664 -Cryorecovery

应用：MafB-mCherry-Cre knock-in mice express a FLAG-tagged-mCherry fluorescent protein and a Cre Recombinase sequence under the direction of the MafB promoter. These mice are useful for lineage tracing.