型号：GM-J#029656 -Cryorecovery

应用：Slc6a11-Cre/ERT2 BAC transgenic mice have tamoxifen-inducible Cre recombinase expression directed at moderate levels to astrocytes and neurons. These mice allow inducible genetic manipulations in vivo for studying astrocyte and neuron biology of GAT3+ cells.

型号：GM-J#029655 -Cryorecovery

应用：Aldh1l1-Cre/ERT2 BAC transgenic mice have tamoxifen-inducible Cre recombinase expression directed at high levels to the vast majority of astrocytes, with no detectable expression in neurons. These mice allow pan-astrocytic, specific and inducible genetic manipulations in vivo for studying astrocyte biology at different developmental stages in neural circuitry/synapses, behavior, disease and injury/trauma.

型号：GM-J#029645 -Available

应用：These targeted mutant mice express tamoxifen-inducible cre recombinase from the mouse Postn gene. Expression is restricted to myofibroblasts that have undergone tissue damage (e.g. a myocardial infarction event).

型号：GM-J#029633 -Available

应用：CAGs-LSL-RIK (or Rosa26-CAGs-LSL-RIK) knock-in has a CAG promoter and loxP-flanked STOP cassette upstream of the third-generation reverse tetracycline-regulated transactivator gene (rtTA3), IRES sequence and the monomeric far-red fluorescent protein mKate2, all inserted into the Gt(ROSA)26Sor locus. These mice are a Cre recombinase-dependent, Tet-On and fluorescent tool strain - following removal of the floxed-STOP cassette, they allow dox-conditional expression of TRE promoter-driven target genes in conjunction with mKate2 fluorescence.

型号：GM-J#029626 -Cryorecovery

应用：The Lck-GCaMP6fflox (or R26-Lck-GCaMP6fflox) knock-in mice have Cre-dependent expression of a plasma membrane-targeted GCaMP6f. Lck-GCaMP6f is a detector of single neuronal action potentials with fast response kinetics. It has an Lck-tag to improve its ability to reveal calcium signals in near membrane regions and fine processes (e.g., astrocyte processes). After Cre exposure, bright GCaMP6f fluorescence is observed following calcium binding (such as neuronal activation).

型号：GM-J#029619 -Cryorecovery

应用：IL-2cre knock-in mice express Cre recombinase under the direction of the IL-2 promoter. These mice are useful for labelling CD4+ T cells in lung, bone marrow, spleen, Peyer’s Patches, mesenteric lymph nodes, and intraepithelial lymphocytes and lamina propria of small intestine.

型号：GM-J#029617 -Cryorecovery

应用：The CAGs-LSL-rtTA3 (or Rosa26-CAGs-LSL-rtTA3) knock-in allele has a CAG promoter and loxP-flanked STOP cassette upstream of the third-generation reverse tetracycline-regulated transactivator gene (rtTA3), all inserted into the Gt(ROSA)26Sor locus. These mice are a Cre recombinase-dependent, Tet-On tool strain - following removal of the floxed-STOP cassette, they allow dox-conditional expression of TRE promoter-driven target genes.

型号：GM-J#029594 -Not Available At Jax

应用：Stock No. 029594 has been discontinued. We recommend B6.Cg-Tg(Dmp1-cre/ERT2)0022Pdp/IkalJ (Stock No. 032757) as a replacement.

型号：GM-J#029588 -Cryorecovery

应用：Ntng2-IRES2-Cre-D knock-in mice are designed to have Cre recombinase expression directed to netrin G2-expressing Cre recombinase expression and activity largely recapitulates the endogenous Ntng2 gene - it is enriched in claustrum but relatively sparse in nearby structures (anterior dorsal nucleus, taenia tecta and endopiriform nucleus). These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping related to this netrin G protein, such as axon guidance.

型号：GM-J#029587 -Cryorecovery

应用：Gnb4-IRES2-Cre-D knock-in mice are designed to have Cre recombinase expression directed to guanine nucleotide binding protein (G protein) beta 4-expressing cells. Cre recombinase expression and activity largely recapitulates the endogenous Gnb4 gene - it is enriched in claustrum but relatively sparse in nearby structures (endopiriform nucleus and deep insular cortex). These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping related to this G protein.