型号：GM-J#034103 -Cryorecovery

应用：Ai175 (also called Ai175(TIT2L-EGFP-shOct4-ICL-tdT-tTA2)) is a Cre-dependent, Tet-controllable transcription tool strain with dual fluorescent reporters, created by targeted insertion at the Igs7 locus (TIGRE). Exposure to Cre recombinase removes both STOP cassettes, resulting in tTA2 expression, robust tdTomato fluorescence and EGFP/shOct4 fusion protein expression (robust EGFP fluorescence and potential knockdown of endogenous Pou5f1 expression by short hairpin RNA shOct4). The EGFP/shOct4 expression may be expected to be diminished/eliminated by doxycycline.

型号：GM-J#034102 -Cryorecovery

应用：Ai174 (also called Ai174(TIT2L-EGFP-shHDAC1-ICL-tdT-tTA2)) is a Cre-dependent, Tet-controllable histone deacetylation tool strain with dual fluorescent reporters, created by targeted insertion at the Igs7 locus (TIGRE). Exposure to Cre recombinase removes both STOP cassettes, resulting in tTA2 expression, robust tdTomato fluorescence and EGFP/shHDAC1 fusion protein expression (robust EGFP fluorescence and potential knockdown of endogenous histone deacetylase 1 expression by short hairpin RNA shHDAC1). The EGFP/shHDAC1 expression may be expected to be diminished/eliminated by doxycycline.

型号：GM-J#034101 -Cryorecovery

应用：Ai173 (also called Ai173(TIT2L-EGFP-HDAC1-ICL-tdT-tTA2)) is a Cre-dependent, Tet-controllable histone deacetylation tool strain with dual fluorescent reporters, created by targeted insertion at the Igs7 locus (TIGRE). Exposure to Cre recombinase removes both STOP cassettes, resulting in tTA2 expression, robust tdTomato fluorescence and EGFP/HDAC1 fusion protein expression. HDAC1 is a potent epigenetic regulator and its overexpression will promote histone deacetylation. EGFP/HDAC1 expression may be expected to be diminished/eliminated by doxycycline.

型号：GM-J#034100 -Cryorecovery

应用：Ai140 (also called Ai140(TIT2L-EGFP-ICL-tTA2)) is a Cre-dependent, Tet-controllable fluorescent reporter line, created by targeted insertion at the Igs7 locus (TIGRE). Exposure to Cre recombinase removes both STOP cassettes - resulting in tTA2 expression and robust EGFP fluorescence. EGFP expression may be expected to be diminished/eliminated by doxycycline.

型号：GM-J#034099 -Cryorecovery

应用：Ai139 (also called Ai139(TIT2L-EGFP-ICL-TPT)) is a Cre-dependent, Tet-controllable dual fluorescent reporter line, created by targeted insertion at the Igs7 locus (TIGRE). Exposure to Cre recombinase removes both STOP cassettes resulting in tTA2 expression, robust EGFP fluorescence and robust tdTomato fluorescence. EGFP expression may be diminished/eliminated by doxycycline.

型号：GM-J#034000 -Cryorecovery

应用：Tcerg1l-2A-CreER knock-in mice express tamoxifen-inducible CreERT2 fusion protein from the mouse Tcerg1l (transcription elongation regulator 1-like) promoter in TCERG1L-positive neurons of the neocortex, hypothalamus and tectum.

型号：GM-J#033999 -Cryorecovery

应用：Adcyap1-2A-CreER knock-in mice express tamoxifen-inducible CreERT2 fusion protein from the mouse Adcyap1 (adenylate cyclase activating polypeptide 1) promoter in ADCYAP1-positive neurons of the neocortex and pons.

型号：GM-J#033984 -Cryorecovery

应用：These β-actin-cre transgenic mice express Cre recombinase directed by the human beta actin gene promoter. Cre recombinase activity is widespread in the embryo by the blastocyst stage of development.

型号：GM-J#033969 -Cryorecovery

应用：Rln3-Cre mice (also called Rln3-IRES-Cre/GFP) are designed to have the endogenous relaxin 3 promoter/enhancer driving Cre/GFP fusion protein expression to nucleus incertus (NI) of the pontine tegmentum (a subset of NI GABAergic neurons) and to smaller populations of Rln3-expressing neurons found in the periaqueductal gray and adjacent to the substantia nigra. While Rln3-Cre was designed to retain endogenous Rln3 expression, this allele is hypomorphic; as such it is recommended that Rln3-Cre heterozygotes be used for Cre-lox applications. These mice may be used to generate conditional mutations in RLN3+ cells for studying physiological processes such as stress, memory and appetite regulation, as well as neuropeptide signaling processes.

型号：GM-J#033951 -Available

应用：Dbhcre knock-in/knock-out mice express Cre recombinase from the endogenous Dbh locus, abolishing endogenous Dbh gene expression. Cre recombinase activity is detected in noradrenergic neurons.