型号：GM-J#034516 -Cryorecovery

应用：DNAJC6 R857G knock-in mice carry an R857G (arginine to glycine) substitution in the Dnajc6 (DnaJ heat shock protein family (Hsp40) member C6) gene. Homozygous adult mice develop abnormal motor phenotypes. This strain may be useful for studying juvenile Parkinsonism.

型号：GM-J#034497 -Cryorecovery

应用：Gdf15nuGFP-CE knock-in/knock-out mice have a nuclear GFP reporter followed by an inducible Cre/ERT2 inserted into intron 1 of the growth differentiation factor 15 (Gdf15) gene. These mice can be used for lineage tracing in the kidney.

型号：GM-J#034473 -Cryorecovery

应用：The knock-in/knock-out Otx2CreERT2 allele replaces exons 1 and 2 of the orthodenticle homeobox 2 (Otx2) with a tamoxifen-inducible Cre-ERT2 under direction of the endogenous Otx2 promoter. These Otx2CreERT2 mice may be useful in studying neural development, retinal development, cellular proliferation, and medulloblastoma.

型号：GM-J#034470 -Cryorecovery

应用：Csf1r-iCre transgenic mice have codon optimized Cre recombinase (iCre) expression under the direction of the murine colony stimulating factor 1 receptor promoter (Csf1r). iCre recombinase expression is evident in immune cells, including macrophages, dendritic cells and bone marrow derived granulocytes.

型号：GM-J#034467 -Cryorecovery

应用：Ago2Halo-LSL knock-in mice have a HaloTag sequence followed by an in-frame loxP-flanked STOP-IRES-FLAG cassette upstream of the Ago2 first coding exon. Prior to introduction of Cre recombinase, this allele expresses a HaloTag protein and a Flag-Ago2 fusion protein. Cre recombinase exposure deletes the loxP-flanked STOP-IRES-FLAG cassette, which results in expression of the Halo-Ago2 fusion protein. These Ago2Halo-LSL mice allow Halo-enhanced Ago2 pulldown (HEAP) and are useful for identification of miRNA targets (miRNA-mRNA binding sites).

型号：GM-J#034424 -Available

应用：Sncg-IRES2-FlpO-neo knock-in mice are designed to have optimized FLP recombinase expression directed to gamma-synuclein-expressing cells. The donating investigator reports FlpO expression/activity in brain is strong in medulla, cerebellum, midbrain, pons, thalamus, hypothalamus and amygdala. These mice may be used to generate conditional mutations for studying neurodegenerative disorders (e.g., Parkinson's disease), behavior and learning, as well as tumor progression.

型号：GM-J#034408-JAX -Cryorecovery

应用：These double mutant (ht-PAC-305S) mice produce mutated human tau (MAPT), while no endogenous mouse tau (Mapt) is produced. S305S is associated with frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP 17). This mutant mouse strain may be useful in studies of tau isoforms in neurodegenerative disease.

型号：GM-J#034391 -Cryorecovery

应用：Celf4-iCreER mice have a CRISPR/Cas9-generated Celf4-3xHA-P2A-iCreER-T2A-EGFP cassette inserted immediately before the stop codon of the CUGBP, Elav-like family member 4 (Celf4) gene. These mice are useful for visualizing inner ear cochlear spiral ganglion neurons (SGNs) and as a tool for studying SGN developmental and regenerative studies.

型号：GM-J#034382 -Cryorecovery

应用：K13CRE mice express cre recombinase from the mouse Krt13 (keratin 13) promoter in superficial oral, esophageal and urogenital epithelium. Expression is not seen in skin.

型号：GM-J#034320 -Available

应用：This strain serves as a Cre reporter strain. When used in conjunction with a Cre recombinase-expressing strain, successful Cre-mediated excision is indicated by luciferase expression in Cre-expressing tissues.