型号：GM-J#034304 -Cryorecovery

应用：Gpr139-IRES2-FlpO-WPRE knock-in mice are designed to have optimized FLP recombinase expression directed to G protein-coupled receptor 139-expressing cells. FlpO expression/activity is observed in many locations throughout brain, with especially strong expression in olfactory bulb, striatum, lateral septum, hippocampus, amygdala, hypothalamus, midbrain, and strong scattered expression in layer 6 of cortex with less frequent scattered expression in other layers. These mice may be used to generate conditional mutations for studying GPR139 function in motor control, locomotor activity, metabolism, dopaminergic mesolimbic pathways, addiction, Parkinson's disease and schizophrenia.

型号：GM-J#034302 -Cryorecovery

应用：Chrna6-IRES2-FlpO-WPRE-neo knock-in mice are designed to have optimized FLP recombinase expression directed to CHRNA6-expressing cells. FlpO expression/activity is observed in many locations throughout brain, including striatum, lateral geniculate nucleus, superior colliculus, Layer 5 of cortex, medulla, and cerebellum. These mice may be used to generate conditional mutations for studying α6-containing nicotinic acetylcholine receptors, for example, the role of dopaminergic neurons in nicotine addiction or as a possible therapeutic target for Parkinson's disease treatment.

型号：GM-J#034278 -Cryorecovery

应用：Pnoc-IRES-Cre knock-in mice express a Cre recombinase gene inserted upstream of the stop codon of the prepronociceptin (Pnoc) gene. These mice can be used to identify Pnoc expressing cell populations or study pain sensitivity and reward behavior.

型号：GM-J#034261 -Cryorecovery

应用：Ighg3T2A-Cre knock-in mice express Cre recombinase under the direction of the Ighg3 promoter in B-1a cells.

型号：GM-J#034244 -Cryorecovery

应用：HKCreERT2 transgenic mice express a tamoxifen-inducible Cre recombinase directed by mouse Atp4a promoter elements. When induced, Cre recombinase activity is observed in gastric parietal cell.

型号：GM-J#034240 -Cryorecovery

应用：R26-CAG-lsl-CaMPARI2 mice express CaMPARI2 fluorescent calcium reporter from a CAG promoter introduced to the Gt(ROSA)26Sor gene when a loxP-flanked STOP cassette is excised with Cre recombinase. CaMPARI changes from green to red fluorescence with high intracellular calcium and photoconversion light, and is thus useful in monitoring neuronal activity. A poster describing the strain can be found here.

型号：GM-J#034186 -Cryorecovery

应用：Ins1cre knockin/knockout mice express Cre recombinase in insulin-producing beta cells of pancreas starting at birth.

型号：GM-J#034113 -Cryorecovery

应用：Ai213 (also called Ai213(TICL-EGFP-ICF-mOrange2-ICN-mKate2)) is a triple-recombinase responsive reporter allele designed with a CAG promoter, loxP-STOP-loxP and EGFP coding sequence, followed by a CAG promoter, frt-STOP-frt and mOrange2 coding sequence which is followed by a CAG promoter, nox-STOP-nox and mKate2 coding sequence - all inserted into the Igs7 locus (TIGRE). Exposure to either Cre, FLP or Nigri recombinase results in EGFP fluorescence, mOrange2 fluorescence or mKate2 fluorescence, respectively. In total, Ai213 mice are a Cre::FLP::Nigri intersectional fluorescent reporter line designed to allow EGFP/mOrange2/mKate2 fluorescence in those cells where Cre, FLP and Nigri expression overlaps.

型号：GM-J#034112 -Available

应用：Ai195 (also called Ai195(TIT2L-GCaMP7s-ICF-IRES-tTA2)) is a dual-recombinase responsive (Cre/FLP-dependent), Tet-controllable, fluorescent calcium-indicator tool allele created by targeted insertion at the Igs7 locus (TIGRE). Exposure to both Cre and FLP recombinase results in expression of tTA2 and jGCaMP7s (an ultrasensitive EGFP fluorescent calcium detector of neuronal activity with slower decay and response kinetics) in those cells where Cre and FLP expression overlaps/intersects. The jGCaMP7s expression may be expected to be diminished/eliminated by doxycycline. jGCaMP7s has high sensitivity and affinity, improved detection of individual spikes and may allow tracking larger populations of neurons using two-photon imaging.

型号：GM-J#034111 -Cryorecovery

应用：Ai193 (also called Ai193(TICL-EGFP-ICF-tdT)) is a dual-recombinase responsive reporter allele designed with a CAG promoter, loxP-STOP-loxP and EGFP coding sequence followed by a CAG promoter, frt-STOP-frt and tdTomato coding sequence - all inserted into the Igs7 locus (TIGRE). Exposure to either Cre or FLP recombinase results in EGFP fluorescence or tdTomato fluorescence, respectively. Furthermore, Ai193 are a Cre::FLP intersectional fluorescent reporter line as they are designed to allow both EGFP and tdTomato fluorescence in those cells where Cre and FLP expression overlaps.