产品型号：GM-J#033969 -Cryorecovery

产品应用：Rln3-Cre mice (also called Rln3-IRES-Cre/GFP) are designed to have the endogenous relaxin 3 promoter/enhancer driving Cre/GFP fusion protein expression to nucleus incertus (NI) of the pontine tegmentum (a subset of NI GABAergic neurons) and to smaller populations of Rln3-expressing neurons found in the periaqueductal gray and adjacent to the substantia nigra. While Rln3-Cre was designed to retain endogenous Rln3 expression, this allele is hypomorphic; as such it is recommended that Rln3-Cre heterozygotes be used for Cre-lox applications. These mice may be used to generate conditional mutations in RLN3+ cells for studying physiological processes such as stress, memory and appetite regulation, as well as neuropeptide signaling processes.