型号：GM-J#035401 -Available

应用：LysoTag (Rosa26; lox-stop-lox-Tmem192-3xHA) mice conditionally express human TMEM192 cDNA fused to a hemagglutinin (3xHA) tag upon Cre recombinase-mediated excision of a loxP-flanked STOP cassette. Expression of the HA tag enables rapid, tissue-specific, anti-HA antibody-driven immunoisolation of intact lysosomes for content profiling.

型号：GM-J#035400 -Cryorecovery

应用：MORF1 is one of a set of a Cre reporter tool strains (also including MORF3 and TIGRE-MORF) that use mononucleotide repeat frameshift (MORF) as a translation switch for cell labeling in vivo. MORF1 mice express a cre-dependent mNeonGreen fluorescent protein that is proceeded by a polycytosine repeat (C22) MORF switch under the control of a CAG promoter. Cre recombination combined with a spontaneous frameshift results in sparse and stochastic labeling of neural cells.

型号：GM-J#035272 -Cryorecovery

应用：Pitx1/Cre transgenic mice express cre recombinase under the control of the mouse Pitx1 (paired-like homeodomain transcription factor 1) promoter. Cre is expressed in the craniofacial and oral ectoderm as early as E9.5 before the formation of Rathke's pouch, so it is useful for targeting the nascent anterior pituitary gland before the specification of hormone producing cell types.

型号：GM-J#035271 -Cryorecovery

应用：Prop1-Cre mice express cre recombinase from the mouse Prop1 (paired like homeodomain factor 1) gene. Expression of the transgene is found in Rathke's pouch during pituitary organogenesis and in olfactory epithelium beginning at embryonic day 11.5 (E11.5) and declining after birth.

型号：GM-J#035233 -Cryorecovery

应用：MLR10 transgenic mice exhibit cre recombinase expression in both the lens epithelium and lens fibers under the transcriptional control of the mouse Cryaa (crystallin, alpha A) promoter modified by the insertion of a Pax6 consensus binding element/lens epithelial cell enhancer. Cre expression is not found in other parts of the eye.

型号：GM-J#035229 -Available

应用：CRISPR/Cas9 generated CCR2-CreER-GFP mice express cre-ERT2 and EGFP directed from the endogenous chemokine (C-C motif) receptor 2 (Ccr2) promoter. They are useful for applications requiring tamoxifen-induced deletion of floxed sequences in monocytes.

型号：GM-J#035208 -Cryorecovery

应用：hMPO (MPOG) transgenic mice express the intact human myeloperoxidase (MPO) gene bearing a -463G promoter polymorphism, along with introns and flanking regions. This strain is useful in studies of human MPO involvement in models of inflammatory and neurodegenerative diseases, as well as cancer.

型号：GM-J#035186 -Cryorecovery

应用：In these 5-HT3A cKO mice, exon 2 of the mouse Htr3a (5-hydroxytryptamine (serotonin) receptor 3A; also called 5-HT3A) gene was replaced by a cassette consisting of two versions of exon 2: FLP-mediated recombination converts it randomly into HA-mVenus tagged exon 2 or FLAG tagged exon 2. Cre-mediated recombination is anticipated to result in deletion of exon 2 and a knock-out of the gene (not yet confirmed - April, 2020). This is a tool mouse line that will be useful for the community for identification of 5HT3A-receptor positive interneurons.

型号：GM-J#035178 -Cryorecovery

应用：HA-RARalpha KI knock-in mice express hemagglutinin-tagged mouse RARA (retinoic acid receptor, alpha) protein. Cre recombinase-mediated excision of floxed exons 4 and 5 results in the production of hemagglutinin-tagged RARA protein lacking the DNA binding domain.

型号：GM-J#035169 -Available

应用：The inducible KPC:APC mouse model of KRAS mutated colorectal cancer combines the oncogenic conditional KrasG12D allele, the conditional Apcfl allele and a tamoxifen inducible Cre recombinase (CDX2-Cre-ERT2) with cre expression in adult epithelium of the distal intestinal tract. Mice develop malignant colonic tumors 25-30 days post tamoxifen induction.