型号：GM-J#035136 -Cryorecovery

应用：Cre-inducible-Mps1-Knock-in-TA (CiMKiTA) mice carry a Cre-inducible point mutation (T649A) in exon 17 of the Ttk protein kinase (Ttk) gene, expression of which is blocked by the presence of a loxP-flanked cDNA cassette encoding exons 17-22 and a stop codon. This mutation results in a mutant protein similar to that found in human cell lines with a mild chromosomal instability (CIN) phenotype. This strain may be useful when studying oncogenic potential due to the degree and site of chromosomal instability.

型号：GM-J#035093 -Cryorecovery

应用：Krt6-CreERmice have a CRISPR/Cas9 generated insertion of an IRES-Cre/ERT2-SV40pA cassette inserted into the 3' UTR of the Krt6a gene, without disrupting endogenous gene expression. These mice may be used to generate tamoxifen-induced conditional mutations for studying gain-or-loss of function and/or fate mapping related to KRT6A expression during stem cell differentiation.

型号：GM-J#035092 -Available

应用：Sox9-CreER mice have a CRISPR/Cas9 generated insertion of an IRES-Cre/ERT2-SV40pA cassette inserted into the 3' UTR of the Sox9 gene, without disrupting endogenous gene expression. These mice may be used to generate tamoxifen-induced conditional mutations for studying gain-or-loss of function and/or fate mapping related to SOX9 expression during stem cell differentiation.

型号：GM-J#035046 -Cryorecovery

应用：NK1R-CreER knock-in/knock-out mice have the endogenous tachykinin receptor 1 promoter/enhancer sequences directing expression of tamoxifen-inducible Cre recombinase. These mice are a Cre-lox tool allowing inducible Cre recombination in Tacr-expressing cells/tissues (including neurons of the amygdala, hypothalamus, cortex, and spinal cord), and may be useful in studying Substance P signaling, inflammatory responses, and pain.

型号：GM-J#035045 -Cryorecovery

应用：KOR-Cre knock-in/knock-out mice have the endogenous kappa opioid receptor promoter/enhancer sequences directing expression of Cre recombinase. These mice are a Cre-lox tool allowing Cre recombination in Oprk1-expressing cells/tissues (including neurons of the cortex and striatum, retina, lung, liver, and kidney), and may be useful in studying reward, pain, and nociception.

型号：GM-J#034918 -Cryorecovery

应用：Nur77RFP BAC transgenic mice express turbo red/orange fluorescent protein (tRFP) from the mouse Nr4a1 (nuclear receptor subfamily 4, group A, member 1; Nur77) promoter. These mice are useful in studying thymocyte selection as well as lymphocyte activation, and can be used as a reporter of T cell receptor signaling strength.

型号：GM-J#034875 -Cryorecovery

应用：Ndnf-IRES-CreERT2 knock-in mice have a cre/ERT2 fusion gene inserted into the 3' UTR in exon 4 of the neuron-derived neurotrophic factor (Ndnf) gene. These mice retain endogenous Ndnf expression and may be used to generate conditional mutations for studying gain-or-loss of function, fate mapping and/or circuit dissection of NDNF+ cell populations.

型号：GM-J#034859 -Cryorecovery

应用：This compound mutant strain was developed by the JAX Repository by intercrossing NOD.Cg-Tg(CAG-cre/Esr1*)5Amc/J (Stock No. 034795) with NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (Stock No. 005557, commonly known as NSG mice).

型号：GM-J#034801-JAX -Cryorecovery

应用：These microRNA 9-1 conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. LacZ expression is observed in embryonic brain and spinal cord. This mutant mouse strain may be useful in studies of microRNA biology.

型号：GM-J#034800-JAX -Cryorecovery

应用：These microRNA 320 conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. This mutant mouse strain may be useful in studies of microRNA biology.