型号：GM-J#035695 -Cryorecovery

应用：LoxP-STOP-loxP-SAA1 (also called LSL-SAA1) knock-in mice carry a conditional mutant allele in which Saa1 (serum amyloid A 1) and IRES-EGFP are over-expressed from a CAG promoter upon cre recombinase-mediated excision of a loxP-flanked neomycin/Stop cassette. This strain has been useful in studies of Th17 cell responses, inflammation, and autoimmunity. The functionality of the EGFP reporter has not been assessed.

型号：GM-J#035687 -Cryorecovery

应用：H2B::PaGFP mice carry a photoactivatable histone H2B/green fluorescent protein fusion gene (Pa-GFP) behind a floxed STOP cassette (LSL). In the presence of Cre recombinase and photoactivation, bright nuclear fluorescence can be detected, allowing for the observation and measurement of nuclear and chromatin dynamics in vivo.

型号：GM-J#035670 -Available

应用：Vav-Cre transgenic mice express Cre recombinase under the control of the human vav 1 oncogene (VAV1) regulatory elements in all nucleated blood cells as well as hematopoietic stem cells. This strain may be useful as a Cre-lox tool for deletion of floxed sequences in cells of the hematopoietic system.

型号：GM-J#035668 -Cryorecovery

应用：These GATA1-cre transgenic mice express Cre recombinase in most tissues under the control of the mouse GATA binding protein 1 (Gata1) promoter beginning at E10.5. This strain may be useful for generating conditional deletions in developing embryos and in multiple adult tissues. This strain also is available on the 129S background (Stock No. 035667).

型号：GM-J#035667 -Cryorecovery

应用：These GATA1-cre transgenic mice express Cre recombinase in most tissues under the control of the mouse GATA binding protein 1 (Gata1) promoter beginning at E10.5. This strain may be useful for generating conditional deletions in developing embryos and in multiple adult tissues. This strain also is available on the C57BL/6J background (Stock No. 035668).

型号：GM-J#035595 -Cryorecovery

应用：Mice harboring the vil-Cre transgene have the 9-kb mouse, Vil1, villin 1, promoter directing expression of Cre recombinase to the intestinal epithelia and kidney, and may be useful for generating conditional mutations in cells of the crypt–villus axis and kidney. This strain also is available on the C57BL/6N background (Stock No. 033019).

型号：GM-J#035593 -Cryorecovery

应用：Alb-cre transgenic mice express cre recombinase under the control of the mouse albumin enhancer/promoter. This strain may be useful for generating conditional deletions in heptaocytes. This strain also is available on the C57BL/6 background (Stock No. 003574).

型号：GM-J#035576 -Cryorecovery

应用：Tacr3iCre:GFP knock-in mice should express iCre:GFP wherever Tacr3 (tachykinin receptor 3), a G protein-coupled receptor (GPCR), is normally expressed. Mice demonstrate no overt phenotype. Expression levels of the targeted gene have not been assessed, but no effect is anticipated as the insertion is beyond the termination codon.

型号：GM-J#035575 -Cryorecovery

应用：Ptger3Cre:GFP knock-in mice express Cre:GFP wherever Ptger3 (prostaglandin E receptor 3 (subtype EP3)), a G protein-coupled receptor (GPCR), is normally expressed. Heterozygotes demonstrate no overt phenotype. The initiation codon and first 40 amino acids of the protein are deleted, no functional receptor is likely expressed by the targeted allele, but this has not been confirmed. These mice allow cre recombinase-dependent expression of effector/reporter genes in cells that normally express this receptor.

型号：GM-J#035574 -Cryorecovery

应用：Oprm1Cre:GFP knock-in/knock-out mice express Cre:GFP wherever Oprm1 (opioid receptor, mu 1), a G protein-coupled receptor (GPCR), is normally expressed. Heterozygotes demonstrate no overt phenotype. Homozygotes lack mu opioid receptor expression and hence no longer respond to certain endogenous or exogenous ligands. These mice allow cre recombinase-dependent expression of effector/reporter genes in cells that normally express this receptor.