型号：GM-J#036247 -Available

应用：Gls2-CreER knock-in mice have the endogenous Gls2 promoter/enhancer sequences directing expression of tamoxifen-inducible Cre recombinase. These mice are a Cre-lox tool allowing inducible Cre recombination in Gls2-expressing cells/tissues (including hepatocytes surrounding the portal vein in zone 1), and may be useful in studying hepatocyte proliferation, organization and function.

型号：GM-J#036246 -Available

应用：Cyp1a2-CreER knock-in mice have the endogenous Cyp1a2 promoter/enhancer sequences directing expression of tamoxifen-inducible Cre recombinase. These mice are a Cre-lox tool allowing inducible Cre recombination in Cyp1a2-expressing cells/tissues (including hepatocytes surrounding the central vein in zones 2 and 3), and may be useful in studying hepatocyte proliferation, organization and function.

型号：GM-J#036235 -Cryorecovery

应用：Cxcl12-creER transgenic mice express a tamoxifen-inducible (ERT2) codon-improved iCre recombinase directed by mouse Cxcl12 (chemokine (C-X-C motif) ligand 12) promoter elements. When induced, iCre recombinase activity is observed in a subset of bone marrow stromal cells. This strain may be useful for in vivo lineage tracing and functional analysis of skeletal regeneration.

型号：GM-J#036209 -Cryorecovery

应用：Six3-CreERT2 (Six3+/-) knock-in/knock-out mice have cre/ERT2 cDNA replacing part of exon 1 of the sine oculis-related homeobox 3 (Six3) gene. They are useful for studying Holoprosencephaly (HPE).

型号：GM-J#036203 -Available

应用：ER-BioIDHA (Secretome) knock-in mice have a CAG promoter controlling the Cre-inducible expression of a ER-BioID2HA fusion protein. Cre-mediated recombination results in the secretion of biotinylated proteins in a tissue-specific fashion when given exogenous biotin in their diet. These mice provide a genetic platform to delineate tissue-specific in vivo secretion.

型号：GM-J#036159 -Available

应用：Gba1E326K mice carry a CRISPR/Cas9-generated E344K knock-in in exon 8 of the mouse Gba1 (glucosidase, beta, acid 1) gene. This mutation corresponds to a human coding variant potentially associated with increased susceptibility to familial Parkinson's disease. Homozygotes show ~30-40% reduction in glucocerebrosidase (GCase) activity in whole brain tissue as well as a decrease in the total protein.

型号：GM-J#036087 -Not Available At Jax

应用：Rosa26-H2BTom mice express a Cre-inducible H2B/RFP from the Gt(ROSA)26Sor locus. These mice are useful in studies where a red nuclear-localized Cre reporter is desired.

型号：GM-J#036065-JAX -Cryorecovery

应用：These microRNA 187 conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. This mutant mouse strain may be useful in studies of microRNA biology.

型号：GM-J#036064-JAX -Cryorecovery

应用：These microRNA 196a-1 conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. This mutant mouse strain may be useful in studies of microRNA biology.

型号：GM-J#036063-JAX -Cryorecovery

应用：These microRNA 219-2 conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. This mutant mouse strain may be useful in studies of microRNA biology.