型号：GM-J#068344-JAX -Cryorecovery

应用：Adgra3cre knock-in/knock-out mice carry a human diphtheria toxin receptor gene (HBEGF) and an inducible Cre recombinase/ERT2 fusion under the control of the Adgra3 (adhesion G protein-coupled receptor A3 or Gpr125) promoter. Embryonic Adgra3 (Gpr125) is expressed in multiple stem cell/progenitor compartments and high expression of Gpr125 is correlated with tumor onset and outcome in several types of cancers. Homozygous mice develop blepharitis, which progresses to blepharedema as well as several characteristics of dry eye syndrome. This strain may be useful in studies of dry eye syndrome as well as in identifying stem/progenitor cells involved in cancers.

型号：GM-J#068163-JAX -Cryorecovery

应用：Foxl1CreERT2-2A-tdTomato knock-in/knock-out mice have an inducible Cre recombinase/ERT2 fusion followed by a tdTomato reporter inserted into the endogenous translation start site of the forkhead box L1 (Foxl1) gene. These mice can be to identify cells in the gastrointestinal tract.

型号：GM-J#068122-JAX -Cryorecovery

应用：Tg(Tshb-cre) transgenic mice express a cre recombinase directed by mouse Tshb (thyroid stimulating hormone, beta subunit) promoter elements. Cre recombinase activity is observed in pituitary thyrotroph cells. This strain may be useful for in vivo lineage tracing and functional analysis of thyrotrophs.

型号：GM-J#068075-JAX -Cryorecovery

应用：Nanog-creER transgenic mice express a tamoxifen-inducible (Esr1*) Cre recombinase directed by mouse Nanog (Nanog homeobox) promoter elements. When induced, Cre recombinase activity is observed in embryonic stem cells. This strain may be useful for in vivo lineage tracing.

型号：GM-J#068059-JAX -Cryorecovery

应用：Pou3f4 knock-in/knock-out mice contain a Cre recombinase that replaces the Pou3f4 (POU domain, class 3, transcription factor 4) coding region. Females homozygous for the mutation and males hemizygous for the X-linked mutation are deaf due to reduced endocochlear potential; mutants also show a failure of auditory spiral ganglion neuron radial bundle fasciculation and synapse formation in the cochlea.

型号：GM-J#067446-JAX -Cryorecovery

应用：Ambn-IRESCre knock-in mice are designed to have the endogenous Ambn promoter/enhancer regions directing expression of cre recombinase to the tooth, with minimal disruption to endogenous Ambn (ameloblastin) expression. These mice are useful for studying dental enamel development.

型号：GM-J#067402-JAX -Cryorecovery

应用：Odam-IRESCre knock-in mice are designed to have the endogenous Odam promoter/enhancer regions directing expression of cre recombinase to the tooth, with minimal disruption to endogenous Odam expression. These mice are useful for studying tooth enamel and periodontitis.

型号：GM-J#067177-JAX -Cryorecovery

应用：R26-O2CreER(T2) mice express the oxygen-dependent degradation (ODD) domain from human HIF1A fused with an inducible Cre recombinase gene, all inserted into the ROSA26 locus. In combination with a loxP-flanked reporter, progeny can be used as a tamoxifen-inducible hypoxia-sensing model.

型号：GM-J#065813-JAX -Cryorecovery

应用：Sned1LacZ-Neo mice carry a knock-out first, conditional-ready, lacZ-tagged allele of the mouse Sned1 gene. Most homozygotes die within 2 days of being born. The rare knock-out survivors present severe craniofacial defects (shorter snouts, asymmetrical nasal cavities) and growth retardation.

型号：GM-J#050696-JAX -Cryorecovery

应用：Adh7 (alcohol dehydrogenase 7 (class IV) or Adh4) knock-out mice exhibit an impaired ability to metabolize a number of substrates including retinol (vitamin A), ethanol and dopamine.