型号：GM-J#009388 -Cryorecovery

应用：These Osr2-IresCre (or Osr2IresCre) mice harbor an IRES-Cre inserted into the 3' UTR of Osr2 (odd-skipped related 2 (Drosophila)) locus. When bred with mice containing a loxP-flanked sequence, Cre-mediated recombination will result in deletion of the floxed sequence primarily in developing palate mesenchyme and metanephric mesenchyme-derived glomeruli tissues in the offspring. These mice may be useful for generating conditional mutations for studying developmental biology (palate and kidney development).

型号：GM-J#009352 -Cryorecovery

应用：These CDX2P9.5-G22Cre transgenic mice harbor a nuclear-localized Cre recombinase with 22 guanine nucleotide repeat between initiating methionine (ATG) codon and the remainder of the coding region altering the cre reading frame. Presumably, following a somatic mutation that results in some frameshift mutation(s) in the guanine nucleotide tract in a subset of somatic cells, resultant expression of a functional Cre recombinase is driven by a 9.5 kb human caudal type homeo box 2 (CDX2) promoter/enhancer sequence. These CDX2P9.5-G22Cre transgenic mice may be useful as a somatic mutation reporter strain and/or to generate conditional mutations in colorectal epithelial cells.

型号：GM-J#009350 -Cryorecovery

应用：These transgenic mice express a nuclear-localized Cre recombinase under the control of a human CDX2 promoter/enhancer sequence and may be useful for generating conditional mutations in colonic epithelial cells.

型号：GM-J#009347 -Cryorecovery

应用：Mice homozygous for the LRRK2 R1441C knockin (R1441C KI) express the R1441C mutant form of leucine-rich repeat kinase 2 (Lrrk2) associated with Parkinson's disease. These LRRK2 R1441C KI mice may be useful in studying abnormal regulation of activity-dependent dopamine neurotransmission and D2 receptor-mediated function, which may represent pathogenic precursors preceding dopaminergic degeneration in Parkinson's disease.

型号：GM-J#009346 -Cryorecovery

应用：Mice homozygous for the LRRK2 R1441C knockin allele express the R1441C mutant form of leucine-rich repeat kinase 2 (Lrrk2) associated with Parkinson's disease. These LRRK2 R1441C KI mice may be useful in studying abnormal regulation of activity-dependent dopamine neurotransmission and D2 receptor-mediated function, which may represent pathogenic precursors preceding dopaminergic degeneration in Parkinson's disease.

型号：GM-J#009253 -Cryorecovery

应用：This strain carries an inverted human placental alkaline phosphatase (ALPP; PLAP) coding segment flanked by oppositely-oriented loxP sites integrated in the Gt(ROSA)26Sor gene. Cre excision of the floxed segment flips rather than excises the ALPP inversion and reinstates a transcriptionally active form of the gene. This reporter can be activated by tissue-specific cre recombinase in any cell in the body at any time in development. The result is very clear ALPP enzyme activity that can be detected histochemically.

型号：GM-J#009155 -Cryorecovery

应用：This targeted strain expresses Cre under the control of the claudin 6 promoter. When bred to a floxed reporter strain, broad expression throughout the epiblast is seen at E6.5. By E9.5, expression is restricted to the endoderm-derived structures such as the oral cavity, digestive tract, and lung. In addition, it is expressed in mesonephros and otic vesicle.

型号：GM-J#009117 -Cryorecovery

应用：These Cyp39a1-Tg7-Cre mice express Cre recombinase under the control of the Cyp39a1 (cytochrome P450, family 39, subfamily a, polypeptide 1) promoter/enhancer regions, and may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping in subgroups of brain tissues (including cortex, hippocampus and cerebellum).

型号：GM-J#009112 -Cryorecovery

应用：These Scnn1a-Tg2-Cre mice express Cre recombinase under the control of the Scnn1a (sodium channel, nonvoltage-gated 1 alpha) promoter/enhancer regions, and may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping in subgroups of brain tissues (including cortex, thalamus, midbrain and cerebellum).

型号：GM-J#009111 -Cryorecovery

应用：These Scnn1a-Tg1-Cre mice express Cre recombinase under the control of the Scnn1a (sodium channel, nonvoltage-gated 1 alpha) promoter/enhancer regions, and may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping in subgroups of brain tissues (including cortex, striatum, hippocampus and cerebellum).